{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:44:12Z","timestamp":1782819852450,"version":"3.54.5"},"reference-count":21,"publisher":"Ubiquity Press, Ltd.","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016206","name":"UCLA Clinical and Translational Science Institute","doi-asserted-by":"crossref","award":["UL1TR001881"],"award-info":[{"award-number":["UL1TR001881"]}],"id":[{"id":"10.13039\/100016206","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TOHM"],"abstract":"<jats:p>Background: Anecdotal evidence suggests paradoxical caffeine overuse in individuals with Huntington\u2019s disease (HD). A small retrospective study associated caffeine intake over 190 grams daily to earlier onset of HD symptoms. However, specific data on consumption habits is limited. This study aims to gather pilot data on caffeine use in people with HD, exploring motivations and consequences.\nMethods: Thirty adults with HD completed a survey on daily caffeine intake, its impact on symptoms, and consumption motivations through multiple-choice and open-ended questions. Descriptive statistics were used to analyze findings and compare them to general population data.\nResults: Caffeine intake ranged from 0 to 1400.4 mg\/day, with a median of 273.2 mg\/day and a mean of 382.5 mg\/day. Seventy percent of participants with HD consumed more caffeine than the average for their age group in the general population. Additionally, 20% of participants and 38% of family members believed caffeine influenced HD symptoms, primarily anxiety.\nDiscussion: People with HD typically consume more caffeine than the general U.S. population. Contrary to the hypothesis, higher caffeine intake was not associated with significant subjective worsening of HD symptoms. Further research with objective measures and multiple HD centers is necessary to guide screening and counseling on caffeine use in this population.\nHighlights\nParticipants with Huntington\u2019s disease (HD) had increased caffeine intake compared to the general population, supporting previous anecdotal observations. Anxiety was the most affected HD symptom. Further research using objective measures of symptom burden and including multiple HD centers can help inform screening and counseling regarding caffeine use in this population.<\/jats:p>","DOI":"10.5334\/tohm.945","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T08:12:19Z","timestamp":1729239139000},"page":"52","source":"Crossref","is-referenced-by-count":1,"title":["Caffeine Use in Huntington&amp;rsquo;s Disease: A Single Center Survey"],"prefix":"10.5334","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4400-7442","authenticated-orcid":false,"given":"Jennifer","family":"Adrissi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-3124","authenticated-orcid":false,"given":"Sarah","family":"Brooker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-1549","authenticated-orcid":false,"given":"Alyssa","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-6614","authenticated-orcid":false,"given":"Danielle","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gausche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Bega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3285","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"4","key":"key20241018121211_B1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/cns.12684","article-title":"The neuroprotective effects of caffeine in neurodegenerative diseases","volume":"23","year":"2017","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"key20241018121211_B2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.nbd.2009.06.009","article-title":"A genetic variation in the ADORA2 A gene modifies age at onset in Huntington\u2019s disease","volume":"35","year":"2009","journal-title":"Neurobiol Dis"},{"issue":"4","key":"key20241018121211_B3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10048-010-0248-3","article-title":"Age at onset in Huntington\u2019s disease: replication study on the associations of ADORA2 A, HAP1 and OGG1","volume":"11","year":"2010","journal-title":"Neurogenetics"},{"issue":"2","key":"key20241018121211_B4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.nbd.2010.09.021","article-title":"A2 A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington\u2019s disease","volume":"41","year":"2011","journal-title":"Neurobiol Dis"},{"issue":"2","key":"key20241018121211_B5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-4159.2005.03029.x","article-title":"CGS21680 attenuates symptoms of Huntington\u2019s disease in a transgenic mouse model","volume":"93","year":"2005","journal-title":"J Neurochem"},{"issue":"16","key":"key20241018121211_B6","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1093\/hmg\/ddp230","article-title":"The A2 A adenosine receptor rescues the urea cycle deficiency of Huntington\u2019s disease by enhancing the activity of the ubiquitin-proteasome system","volume":"18","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"6","key":"key20241018121211_B7","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.pharep.2014.07.006","article-title":"Improvement of mitochondrial NAD(+)\/FAD(+)-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: implications in Huntington\u2019s disease","volume":"66","year":"2014","journal-title":"Pharmacol Rep"},{"issue":"1","key":"key20241018121211_B8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12192-017-0824-7","article-title":"Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans","volume":"23","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"key20241018121211_B9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nbd.2013.05.013","article-title":"Association between caffeine intake and age at onset in Huntington\u2019s disease","volume":"58","year":"2013","journal-title":"Neurobiol Dis"},{"issue":"1","key":"key20241018121211_B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.29.1.1","article-title":"Huntington disease: clinical care and evaluation","volume":"29","year":"1979","journal-title":"Neurology"},{"key":"key20241018121211_B11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fct.2013.10.042","article-title":"Beverage caffeine intakes in the U.S","volume":"63","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"key20241018121211_B12","unstructured":"Kantar Worldpanel Online Data Delivery and Analysis Tool. Available at: https:\/\/www.kantarworldpanel.com\/global\/Countries."},{"key":"key20241018121211_B13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fct.2013.10.042","article-title":"Beverage caffeine intakes in the U.S","volume":"63","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"#cr-split#-key20241018121211_B14.1","unstructured":"Food Insight. Caffeine: Consumer Consumption Habits and Safety Perceptions [Internet]. [updated date - 2022 March 15"},{"key":"#cr-split#-key20241018121211_B14.2","unstructured":"cited - 2023 July 10]. Available from: https:\/\/foodinsight.org\/wp-content\/uploads\/2022\/03\/IFIC-Caffeine-Survey.March-2022.pdf."},{"issue":"2","key":"key20241018121211_B15","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.clnu.2018.04.004","article-title":"Intake of caffeine from all sources and reasons for use by college students","volume":"38","year":"2019","journal-title":"Clinical nutrition"},{"issue":"1","key":"key20241018121211_B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JHD-180335","article-title":"Obsessive-Compulsive and Perseverative Behaviors in Huntington\u2019s Disease","volume":"8","year":"2019","journal-title":"Journal of Huntington\u2019s disease"},{"issue":"5","key":"key20241018121211_B17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/hrp\/7.5.278","article-title":"Huntington\u2019s disease and its association with psychopathology","volume":"7","year":"2000","journal-title":"Harvard review of psychiatry"},{"key":"key20241018121211_B18","article-title":"Anosognosia in HD: Comparison of self-report and caregiver ratings with objective performance measures","volume":"107","year":"2023","journal-title":"Parkinsonism & related disorders"},{"key":"key20241018121211_B19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"The Unified Huntington\u2019s Disease Rating Scale: Reliability and Consistency","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov Dis"},{"issue":"1","key":"key20241018121211_B20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-0327(88)90072-9","article-title":"The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders","volume":"14","year":"1988","journal-title":"J Affect Disord"}],"container-title":["Tremor and Other Hyperkinetic Movements"],"original-title":[],"link":[{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/945\/1920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/945\/1921","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/945\/1922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/945\/1920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:47:07Z","timestamp":1782816427000},"score":1,"resource":{"primary":{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/view\/945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":21,"URL":"https:\/\/doi.org\/10.5334\/tohm.945","relation":{},"ISSN":["2160-8288"],"issn-type":[{"value":"2160-8288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]}}}