{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:35:26Z","timestamp":1788820526666,"version":"build-2803163510"},"reference-count":48,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    We conducted a retrospective cohort study to evaluate the clinical manifestations, laboratory findings, complications and treatment of brucellosis in the State of Qatar.\n                    <jats:bold>Methods:<\/jats:bold>\n                    The medical records of patients in Hamad Medical Corporation, Doha, Qatar were reviewed from January 2000 to December 2006. History, various socio-demographic features, clinical and biochemical parameters, therapeutic features, and complications were retrospectively collected from the patient database.\n                    <jats:bold>Results:<\/jats:bold>\n                    Around three quarters of the study population were males. History of raw milk consumption and animal contact were seen in 41.7% and 12.5% respectively. The main presenting features of our cohort were fever, chills and sweating (93.1%, 62.5% and 58.3% respectively). Positive antibody titre (&gt;1:160) was detected in 95.8% and positive blood culture was reported in 63.9% of the cohort. Splenomegaly was observed in 19.4%, hepatomegaly in 15.3% and lymphadenopathy in 9.7% of the cases. Approximately half of our patients were treated with a combination of doxycycline and streptomycine and nearly one quarter received doxycycline and rifampicine combination therapy.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Brucellosis is an important public health problem worldwide. It is associated with significant morbidity and mortality. It may affect any organ system and can present with a variety of clinical features. Diagnosis of brucellosis requires serological tests with or without blood culture. Treatment with at least two antibiotics for six weeks or more appears to be effective.\n                  <\/jats:p>","DOI":"10.5339\/qmj.2014.4","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T23:49:56Z","timestamp":1406159396000},"source":"Crossref","is-referenced-by-count":13,"title":["Brucellosis in Qatar: A retrospective cohort study"],"prefix":"10.5339","volume":"2014","author":[{"given":"Ali Ibrahim","family":"Rahil","sequence":"first","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muftah","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Yahya","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3277","reference":[{"key":"CIT0001","series-title":"Lancet Infect Dis","first-page":"91","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas\n\u00a0\nG","year":"2006"},{"key":"CIT0002","series-title":"East Mediterr Health J","first-page":"225","article-title":"Human brucellosis in the Gaza strip, Palestine","volume":"4","author":"Awad\n\u00a0\nR","year":"1998"},{"issue":"8271","key":"CIT0003","series-title":"Lancet","first-page":"574","article-title":"Transmission of brucellosis by bone marrow transplantation","volume":"1","author":"Naparstek\n\u00a0\nE","year":"1982"},{"issue":"2","key":"CIT0004","series-title":"Trop Geogr Med","first-page":"151","article-title":"Probable transmission of brucellosis from breast milk to a newborn","volume":"40","author":"Lubani\n\u00a0\nM","year":"1988"},{"issue":"9017","key":"CIT0005","series-title":"Lancet","first-page":"1763","article-title":"Brucella melitensis\u2013a sexually transmissible agent?","volume":"347","author":"Mantur\n\u00a0\nBG","year":"1996"},{"issue":"4","key":"CIT0006","series-title":"J Trop Pediatr","first-page":"272","article-title":"Brucellar meningitis in an infant\u2013evidence for human breast milk transmission","volume":"54","author":"Tikare\n\u00a0\nNV","year":"2008"},{"key":"CIT0007","series-title":"J Assoc Physicians India","first-page":"271","article-title":"Hospital-based case series of 175 cases of serologically confirmed brucellosis in Bikaner","volume":"55","author":"Kochar\n\u00a0\nDK","year":"2007"},{"issue":"3","key":"CIT0008","series-title":"Indian J Med Microbiol","first-page":"188","article-title":"Review of clinical and laboratory features of human brucellosis","volume":"25","author":"Mantur\n\u00a0\nBG","year":"2007"},{"issue":"3","key":"CIT0009","series-title":"Rev Infect Dis","first-page":"531","article-title":"Osteoarticular complications of brucellosis: a study of 169 cases","volume":"9","author":"Mousa\n\u00a0\nAR","year":"1987"},{"key":"CIT0010","series-title":"Brucellosis","first-page":"280","article-title":"Control, eradication and prevention of brucellosis","author":"Nicoletti\n\u00a0\nP","year":"2001"},{"key":"CIT0011","series-title":"Report, Joint FAO\/WHO Expert Committee on Brucellosis","year":"1986"},{"issue":"4","key":"CIT0012","series-title":"Antimicrob Agents Chemother","first-page":"548","article-title":"Comparative trial of rifampin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis","volume":"28","author":"Ariza\n\u00a0\nJ","year":"1985"},{"issue":"Pt 7","key":"CIT0013","series-title":"J Med Microbiol","first-page":"897","article-title":"Protean clinical manifestations and diagnostic challenges of human brucellosis in adults: 16 years\u2019 experience in an endemic area","volume":"55","author":"Mantur\n\u00a0\nBG","year":"2006"},{"key":"CIT0014","series-title":"J Infect Dis","first-page":"85","article-title":"Multivariate model for predicting relapse in human brucellosis","volume":"36","author":"Solera\n\u00a0\nJ","year":"1998"},{"issue":"10","key":"CIT0015","series-title":"Saudi Med J","first-page":"1562","article-title":"Human brucellosis in Northern Saudi Arabia","volume":"26","author":"Fallatah\n\u00a0\nSM","year":"2005"},{"issue":"7","key":"CIT0016","series-title":"Trans R Soc Trop Med Hyg","first-page":"707","article-title":"Brucellosis as a cause of acute febrile illness in Egypt","volume":"101","author":"Jennings\n\u00a0\nGJ","year":"2007"},{"issue":"6","key":"CIT0017","series-title":"Int J Infect Dis","first-page":"e469","article-title":"Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature","volume":"14","author":"Buzgan\n\u00a0\nT","year":"2010"},{"key":"CIT0018","series-title":"Pediatr Int","first-page":"114","article-title":"Presentation, complications, and treatment outcome of brucellosis in Turkish children","volume":"51","author":"Tanir\n\u00a0\nG","year":"2009"},{"key":"CIT0019","series-title":"Klimik Dergisi","first-page":"48","article-title":"Akut brusellozlu hastalarda akut faz reaktanlarinin d\u00fczeyi","volume":"23","author":"Ulug\n\u00a0\nM","year":"2010"},{"key":"CIT0020","series-title":"Infection","first-page":"23","article-title":"Hematological manifestation of childhood brucellosis","volume":"21","author":"Al-Eissa\n\u00a0\nY","year":"1993"},{"key":"CIT0021","series-title":"Turk J Med Sci","first-page":"421","article-title":"Hematological complications in 787 cases of acute brucellosis in eastern Turkey","volume":"38","author":"Dilek\n\u00a0\nI","year":"2008"},{"key":"CIT0022","series-title":"Turk J Med Sci","first-page":"377","article-title":"Complications of Brucella infection among adults: an 18-year retrospective evaluation","volume":"36","author":"Ertek\n\u00a0\nM","year":"2006"},{"key":"CIT0023","series-title":"Trop J Pharm Res","first-page":"303","article-title":"Clinical features, complications and treatment outcome of Brucella infection: ten years\u2019 experience in an endemic area","volume":"8","author":"Bukharie\n\u00a0\nHA","year":"2009"},{"key":"CIT0024","series-title":"QJ Med","first-page":"39","article-title":"Human brucellosis in Kuwait: a prospective study of 400 cases","volume":"66","author":"Lulu\n\u00a0\nAR","year":"1988"},{"key":"CIT0001","series-title":"Lancet Infect Dis","first-page":"91","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas\n\u00a0\nG","year":"2006"},{"key":"CIT0002","series-title":"East Mediterr Health J","first-page":"225","article-title":"Human brucellosis in the Gaza strip, Palestine","volume":"4","author":"Awad\n\u00a0\nR","year":"1998"},{"issue":"8271","key":"CIT0003","series-title":"Lancet","first-page":"574","article-title":"Transmission of brucellosis by bone marrow transplantation","volume":"1","author":"Naparstek\n\u00a0\nE","year":"1982"},{"issue":"2","key":"CIT0004","series-title":"Trop Geogr Med","first-page":"151","article-title":"Probable transmission of brucellosis from breast milk to a newborn","volume":"40","author":"Lubani\n\u00a0\nM","year":"1988"},{"issue":"9017","key":"CIT0005","series-title":"Lancet","first-page":"1763","article-title":"Brucella melitensis\u2013a 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cases","volume":"9","author":"Mousa\n\u00a0\nAR","year":"1987"},{"key":"CIT0010","series-title":"Brucellosis","first-page":"280","article-title":"Control, eradication and prevention of brucellosis","author":"Nicoletti\n\u00a0\nP","year":"2001"},{"key":"CIT0011","series-title":"Report, Joint FAO\/WHO Expert Committee on Brucellosis","year":"1986"},{"issue":"4","key":"CIT0012","series-title":"Antimicrob Agents Chemother","first-page":"548","article-title":"Comparative trial of rifampin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis","volume":"28","author":"Ariza\n\u00a0\nJ","year":"1985"},{"issue":"Pt 7","key":"CIT0013","series-title":"J Med Microbiol","first-page":"897","article-title":"Protean clinical manifestations and diagnostic challenges of human brucellosis in adults: 16 years\u2019 experience in an endemic area","volume":"55","author":"Mantur\n\u00a0\nBG","year":"2006"},{"key":"CIT0014","series-title":"J Infect Dis","first-page":"85","article-title":"Multivariate model for predicting relapse in human brucellosis","volume":"36","author":"Solera\n\u00a0\nJ","year":"1998"},{"issue":"10","key":"CIT0015","series-title":"Saudi Med J","first-page":"1562","article-title":"Human brucellosis in Northern Saudi Arabia","volume":"26","author":"Fallatah\n\u00a0\nSM","year":"2005"},{"issue":"7","key":"CIT0016","series-title":"Trans R Soc Trop Med Hyg","first-page":"707","article-title":"Brucellosis as a cause of acute febrile illness in Egypt","volume":"101","author":"Jennings\n\u00a0\nGJ","year":"2007"},{"issue":"6","key":"CIT0017","series-title":"Int J Infect Dis","first-page":"e469","article-title":"Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature","volume":"14","author":"Buzgan\n\u00a0\nT","year":"2010"},{"key":"CIT0018","series-title":"Pediatr Int","first-page":"114","article-title":"Presentation, complications, and 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