{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:53:45Z","timestamp":1759179225899,"version":"3.32.0"},"reference-count":32,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:p>\n                  <jats:bold>Background:<\/jats:bold> Hirsutism is a common endocrine problem with high prevalence in Iraqi women. Polycystic ovarian syndrome and idiopathic hirsutism (IH) are the most common etiology of this disorder. There is a clear association between insulin resistance and polycystic ovarian syndrome. However, there is insufficient data on the relationship between insulin resistance and IH.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim:<\/jats:bold> The aim of this study was to determine whether Iraqi women with IH have insulin resistance.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> The study included two groups: 60 Iraqi women with IH and 60 women without hirsutism as a control group. A physical examination, a medical history, and the patient's age and BMI were collected. Blood samples were collected for hormone analysis, including insulin, follicle-stimulating hormone, luteinizing hormone, prolactin, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, and free testosterone. To evaluate insulin resistance in both groups, the homeostasis model assessment-insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) were used in addition to the Matsuda index.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Basal insulin was higher in the IH group (9.5\u00a0\u00b1\u00a00.2 mIU\/L) than in the control group (4.8\u00a0\u00b1\u00a03.7 mIU\/L), with a <jats:italic>p<\/jats:italic> value of &lt;\u00a00.0001. HOMA-IR was higher in the IH group (2.3\u00a0\u00b1\u00a04.1 \u03bcU mg), while in the control group, it was (0.8\u00a0\u00b1\u00a01.2 \u03bcU mg), with a <jats:italic>p<\/jats:italic> value of 0.007. There was a significant difference in the QUICKI, which was lower in the IH group (0.31\u00a0\u00b1\u00a00.2 \u03bcU<jats:sup>-1<\/jats:sup>\/mg) than in the control group (0.45\u00a0\u00b1\u00a00.1 \u03bcU<jats:sup>-1<\/jats:sup>\/mg), with a <jats:italic>p<\/jats:italic> value of &lt;\u00a00.0001. The insulin sensitivity index (Matsuda) was significantly lower in the IH group (3.1\u00a0\u00b1\u00a00.4) than in the control group (7.8\u00a0\u00b1\u00a01.3), with a <jats:italic>p<\/jats:italic> value of &lt;\u00a00.0001.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> According to the results of this study, Iraqi women with IH have insulin resistance and higher basal insulin levels.<\/jats:p>","DOI":"10.5339\/qmj.2024.72","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T08:50:43Z","timestamp":1736412643000},"source":"Crossref","is-referenced-by-count":1,"title":["Insulin resistance in Iraqi women with idiopathic hirsutism in Najaf City: A case\u2013control study"],"prefix":"10.5339","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-8782","authenticated-orcid":true,"given":"Maysam","family":"Alaasam","sequence":"first","affiliation":[{"name":"College of Medicine, University of Kufa, Kufa, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalal","family":"Al-bdairi","sequence":"additional","affiliation":[{"name":"Endocrine and Diabetes Center, Najaf, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffat","family":"Abboodi","sequence":"additional","affiliation":[{"name":"Alnajaf Teaching Hospital, Najaf, Iraq\n*Correspondence: Maysam Alaasam. 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