{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:53:16Z","timestamp":1777312396918,"version":"3.51.4"},"reference-count":20,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Malignant syphilis is a rare form of secondary syphilis that occurs mainly in patients living with human immunodeficiency virus (HIV), with approximately 15 cases reported in the last century. We present the case of a patient treated in our institution.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case presentation:<\/jats:bold>\n                    A 25-year-old male patient presented with round lesions in the form of ulcerations with blackish crust on the plantar area and inner edge of the right foot. VDRL (venereal disease research laboratory) test and ELISA (enzyme-linked immunosorbent assay) were performed for the diagnosis of syphilis and HIV, respectively, which were positive. Subsequently, the patient was hospitalized, and ceftriaxone was indicated due to the lack of crystalline penicillin G in the hospital. Four days later, he had complete improvement of the skin lesions. The patient is currently stable and has no recurrence of skin lesions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    Due to the lack of supplies in our unit, we chose ceftriaxone, which is used in patients with penicillin allergies. The use of this drug has shown good outcomes in different reviews.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Due to the use of appropriate treatment, the patient is currently stable and has no recurrence of skin lesions. Malignant syphilis should be considered as part of the differential diagnosis in patients who present with nodulo-ulcerative lesions and have a positive treponemal or non-treponemal test.\n                  <\/jats:p>","DOI":"10.5339\/qmj.2025.27","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T03:30:26Z","timestamp":1745206226000},"source":"Crossref","is-referenced-by-count":0,"title":["Lues maligna in a patient living with HIV: A case report"],"prefix":"10.5339","volume":"2025","author":[{"given":"Jaime Eugenio","family":"Espinosa-Mora","sequence":"first","affiliation":[{"name":"Departamento de Infectolog\u00eda, Unidad M\u00e9dica de Alta Especialidad No. 25, Instituto Mexicano del Seguro Social, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6181-3908","authenticated-orcid":true,"given":"Mauricio Alejandro","family":"Saldana-Ruiz","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n Hospitalaria de Donaci\u00f3n, Unidad M\u00e9dica de Alta Especialidad No. 25, Instituto Mexicano del Seguro Social, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5789-0232","authenticated-orcid":true,"given":"Karla Monserrat","family":"Ram\u00edrez-Pintor","sequence":"additional","affiliation":[{"name":"Facultad de Medicina UANL, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Ortiz-Alonso","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n Hospitalaria de Donaci\u00f3n, Unidad M\u00e9dica de Alta Especialidad No. 25, Instituto Mexicano del Seguro Social, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8886-1045","authenticated-orcid":true,"given":"Mauricio Linnery","family":"Rend\u00f3n-Saldivar","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n Hospitalaria de Donaci\u00f3n, Unidad M\u00e9dica de Alta Especialidad No. 25, Instituto Mexicano del Seguro Social, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Alberto","family":"Perona-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Unidad M\u00e9dica de Alta Especialidad No. 25, Instituto Mexicano del Seguro Social, Monterrey, Mexico*Correspondence: Mauricio Alejandro Saldana-Ruiz. Email: mauriciomgrr14@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3277","reference":[{"key":"CIT0001"},{"key":"CIT0002","article-title":"Le\u00e7on Theorique et Clinique Sur Les Syphilides Radiquess Par Le Fournier","author":"Bazin\n \nPAE"},{"issue":"(12):","key":"CIT0003","series-title":"N Engl J Med","first-page":"695","article-title":"Syphilis maligna precox \u2014 the first patient seen at MGH in 1821","volume":"296","author":"Cripps\n \nDJ\n,","year":"1977"},{"issue":"(1):","key":"CIT0004","series-title":"Mediterr J Hematol Infect Dis","first-page":"e2015026","article-title":"A case of rupioid syphilis masquerading as aggressive cutaneous lymphoma","volume":"7","author":"Braue\n \nJ\n,","year":"2015"},{"issue":"(2):","key":"CIT0005","first-page":"387\u2013390","article-title":"Lues maligna, or ulceronodular syphilis, in a man infected with human immunodeficiency virus: case report and review","volume":"20","author":"Sands\n 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