{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T21:07:41Z","timestamp":1784408861862,"version":"3.55.0"},"reference-count":28,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Cerebral venous sinus thrombosis (CVST) is an uncommon yet critical complication, especially when arising from heparin-induced thrombocytopenia (HIT). In patients with preexisting conditions such as myasthenia gravis (MG), this correlation adds further complexity to clinical management and outcomes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case presentation:<\/jats:bold>\n                    We report a unique case of CVST induced by HIT in a patient with an established diagnosis of MG. Following plasma exchange therapy, which included heparin administration, the patient developed symptoms indicative of CVST. Diagnostic imaging confirmed thrombosis in the cerebral venous sinuses. Management involved the immediate discontinuation of heparin and the initiation of fondaparinux, leading to effective anticoagulation and clinical improvement.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    This case illustrates the rare intersection of CVST and HIT within the context of MG, underscoring the potential risks associated with heparin therapy in vulnerable patient populations. Early recognition of the signs is essential, as these conditions, in combination, demand prompt and specialized interventions to prevent serious complications.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The successful management of this complex case demonstrates the importance of heightened awareness and proactive strategies in patients with MG undergoing heparin therapy. This report advocates for careful monitoring and tailored treatment to mitigate risks in similarly complex clinical scenarios.\n                  <\/jats:p>","DOI":"10.5339\/qmj.2025.59","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:30:48Z","timestamp":1750141848000},"source":"Crossref","is-referenced-by-count":1,"title":["Cerebral venous sinus thrombosis as a complication of heparin-induced thrombocytopenia in myasthenia gravis: A rare and complex case"],"prefix":"10.5339","volume":"2025","author":[{"given":"Majd A.","family":"AbuAlrob","sequence":"first","affiliation":[{"name":"Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Mantawil","family":"Gumander","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Doha, Qatar*Correspondence: Majd A. AbuAlrob majdaiabualrob72@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Zammar","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah I AL","family":"Qazakzeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Doha, Qatar*Correspondence: Majd A. AbuAlrob majdaiabualrob72@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadi Y.","family":"Alnakhala","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Doha, Qatar*Correspondence: Majd A. AbuAlrob majdaiabualrob72@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama M.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad General Hospital, Doha, Qatar*Correspondence: Majd A. AbuAlrob majdaiabualrob72@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhail","family":"Hussain","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3277","reference":[{"issue":"(3)","key":"CIT0001","series-title":"Stroke","first-page":"664\u201370","article-title":"Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT)","volume":"35","author":"Ferro\n \nJM","year":"2004;"},{"issue":"(10)","key":"CIT0002","series-title":"Eur J Neurol","first-page":"1229\u201335","article-title":"EFNS guideline on the treatment of cerebral venous and sinus thrombosis","volume":"17","author":"Einh\u00e4upl\n \nK","year":"2010;"},{"issue":"(4)","key":"CIT0003","series-title":"Stroke","first-page":"1158\u201392","article-title":"Diagnosis and management of cerebral 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