{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:19:11Z","timestamp":1787563151572,"version":"build-2736575974"},"reference-count":42,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Re-expansion pulmonary edema (REPE) is traditionally associated with the resolution of pneumothorax or pleural effusion. Its occurrence after routine cardiopulmonary bypass (CPB) in cardiac surgery is rare. The incidence of REPE after treatment of pneumothorax or pleural effusion is less than 1%, but it carries a mortality rate of up to 20%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    We present a case of REPE in a 64-year-old male undergoing elective coronary artery bypass grafting. Despite an uneventful surgery and standard perioperative management, the patient developed REPE, manifested with increased airway pressures, blood-tinged secretions, and compromised oxygenation post-CPB. Immediate intervention comprising mechanical ventilation adjustments, diuretics, and vasopressor support was initiated to facilitate recovery. The pulmonary edema resolved within 24 hours after the surgery, and the patient was transferred to the surgical high-dependency unit (HDU) on the third postoperative day.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    This case reports a rare occurrence of REPE following routine CPB and highlights the multifactorial pathogenesis involving reperfusion injury and altered pulmonary physiology. Possible mechanisms include reperfusion injury from free radicals, cytokine release, and increased vascular permeability. The management of REPE requires prompt recognition and treatment and involves diuretics, ventilatory adjustments, and hemodynamic monitoring.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    REPE, though rare post-CPB, requires a high index of suspicion and prompt management to prevent adverse outcomes.\n                  <\/jats:p>","DOI":"10.5339\/qmj.2025.61","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:30:48Z","timestamp":1750141848000},"source":"Crossref","is-referenced-by-count":1,"title":["Re-expansion pulmonary edema after routine use of cardiopulmonary bypass in cardiac surgery: Case report"],"prefix":"10.5339","volume":"2025","author":[{"given":"Abdulaziz","family":"Alkhulaifi","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Shoman","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anesthesia, Hamad Medical Corporation, Doha, Qatar*Correspondence: Adnan Saadeddin saadeddinmd@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Saadeddin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anesthesia, Hamad Medical Corporation, Doha, Qatar*Correspondence: Adnan Saadeddin saadeddinmd@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shady Ashraf","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafeez","family":"Lone","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Maksood","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anesthesia, Hamad Medical Corporation, Doha, Qatar*Correspondence: Adnan Saadeddin saadeddinmd@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3277","reference":[{"issue":"(4)","key":"CIT0001","series-title":"Nagoya J Med Sci","first-page":"647\u201354","article-title":"Incidence of reexpansion pulmonary edema in minimally invasive cardiac surgery","volume":"81","author":"Tamura\n \nT","year":"2019;"},{"issue":"(10)","key":"CIT0002","series-title":"Heliyon","first-page":"e20846","article-title":"Severe noncardiogenic pulmonary edema after cardiopulmonary bypass: case report","volume":"9","author":"Zeng\n \nJ","year":"2023;"},{"issue":"(2)","key":"CIT0003","series-title":"Eur J Cardiothorac Surg","first-page":"500\u20135","article-title":"Re-expansion pulmonary oedema after minimally invasive cardiac surgery with right mini-thoracotomy","volume":"49","author":"Irisawa\n \nY","year":"2016;"},{"issue":"(1)","key":"CIT0004","series-title":"Chest","first-page":"86\u201395","article-title":"Postcardiopulmonary bypass lung edema. A preventable complication?","volume":"103","author":"Louagie\n \nY","year":"1993;"},{"issue":"(2)","key":"CIT0005","series-title":"Indian J Surg","first-page":"174\u20136","article-title":"Reexpansion pulmonary edema","volume":"74","author":"Chakraborty\n \nPP","year":"2012;"},{"issue":"(3)","key":"CIT0006","series-title":"Indian J Crit Care Med","first-page":"343\u20135","article-title":"Re-expansion pulmonary edema-a rare entity: a thin line between pulmonary and cardiac decompensation","volume":"25","author":"Sarna\n \nR","year":"2021;"},{"issue":"(6)","key":"CIT0007","series-title":"J Thorac Cardiovasc Surg","first-page":"868\u201375","article-title":"Fulminating noncardiogenic pulmonary edema. A newly recognized hazard during cardiac operations","volume":"80","author":"Culliford\n \nAT","year":"1980;"},{"issue":"(4)","key":"CIT0008","series-title":"Ann Thorac Surg","first-page":"462\u20134","article-title":"Venovenous extracorporeal membrane oxygenation for noncardiogenic pulmonary edema after coronary bypass surgery","volume":"46","author":"Katz\n \nNM","year":"1988;"},{"issue":"(6)","key":"CIT0009","series-title":"Kyobu Geka","first-page":"417\u201322","article-title":"[Unilateral pulmonary edema during aortic valve replacement through median sternotomy]","volume":"73","author":"Toyama\n \nM","year":"2020;"},{"key":"CIT0010","first-page":"525\u20137","article-title":"Severe re-expansion pulmonary edema after conventional cardiac surgery: identification and management","volume":"34","author":"Vardas\n \nPN","year":"2019;"},{"issue":"(5)","key":"CIT0011","series-title":"Eur J Cardiothorac Surg","first-page":"721\u20137","article-title":"The role of tissue reperfusion in the reexpansion injury of the lungs","volume":"22","author":"Sivrikoz\n \nMC","year":"2002;"},{"issue":"(4)","key":"CIT0012","series-title":"Ann Thorac Cardiovasc Surg","first-page":"205\u20139","article-title":"Reexpansion pulmonary edema","volume":"14","author":"Sohara\n \nY","year":"2008;"},{"issue":"(3)","key":"CIT0013","series-title":"Am J Med","first-page":"497\u2013500","article-title":"Evidence for increased permeability in reexpansion pulmonary edema","volume":"71","author":"Sprung\n \nCL","year":"1981;"},{"issue":"(1)","key":"CIT0014","series-title":"Ann Thorac Surg","first-page":"115\u201322","article-title":"Unilateral postoperative pulmonary edema after: a case-control study","volume":"99","author":"Tutschka\n \nMP","year":"2015;"},{"issue":"(2)","key":"CIT0015","series-title":"J Thorac Cardiovasc Surg","first-page":"237\u201344","article-title":"Cardiopulmonary bypass reduces pulmonary surfactant activity in infants","volume":"118","author":"Griese\n \nM","year":"1999;"},{"issue":"(6)","key":"CIT0016","series-title":"J Cardiothorac Vasc Anesth","first-page":"814\u201322","article-title":"Cardiopulmonary bypass duration is an independent predictor of morbidity and mortality after cardiac surgery","volume":"22","author":"Salis\n \nS","year":"2008;"},{"issue":"(3)","key":"CIT0017","series-title":"J Tehran Heart Cent","first-page":"128\u201331","article-title":"The effect of low tidal volume ventilation during cardiopulmonary bypass on postoperative pulmonary function","volume":"5","author":"Davoudi\n \nM","year":"2010;"},{"issue":"(5)","key":"CIT0018","series-title":"Braz J Cardiovasc Surg","first-page":"694\u2013701","article-title":"The effect of low tidal volume ventilation on inflammatory cytokines during cardiopulmonary bypass","volume":"37","author":"Kank\u0131l\u0131\u00e7\n \nN","year":"2022;"},{"issue":"(4)","key":"CIT0019","series-title":"Perfusion","first-page":"205\u201310","article-title":"Clinical relevance of ventilation during cardiopulmonary bypass in the prevention of postoperative lung dysfunction","volume":"25","author":"Gagnon\n \nJ","year":"2010;"},{"issue":"(5)","key":"CIT0020","series-title":"Chest","first-page":"1843\u201353","article-title":"Low tidal volume mechanical ventilation against no ventilation during cardiopulmonary bypass in heart surgery (MECANO): a randomized controlled trial","volume":"159","author":"Nguyen\n \nLS","year":"2021;"},{"issue":"(1)","key":"CIT0021","series-title":"J Cardiothorac Surg","first-page":"319","article-title":"Effect of ventilation strategy during cardiopulmonary bypass on postoperative pulmonary complications after cardiac surgery: a randomized clinical trial","volume":"16","author":"Zhang\n \nMQ","year":"2021;"},{"issue":"(4)","key":"CIT0001","series-title":"Nagoya J Med Sci","first-page":"647\u201354","article-title":"Incidence of reexpansion pulmonary edema in minimally invasive cardiac surgery","volume":"81","author":"Tamura\n \nT","year":"2019;"},{"issue":"(10)","key":"CIT0002","series-title":"Heliyon","first-page":"e20846","article-title":"Severe noncardiogenic pulmonary edema after cardiopulmonary bypass: case report","volume":"9","author":"Zeng\n \nJ","year":"2023;"},{"issue":"(2)","key":"CIT0003","series-title":"Eur J Cardiothorac Surg","first-page":"500\u20135","article-title":"Re-expansion pulmonary oedema after minimally invasive cardiac surgery with right mini-thoracotomy","volume":"49","author":"Irisawa\n \nY","year":"2016;"},{"issue":"(1)","key":"CIT0004","series-title":"Chest","first-page":"86\u201395","article-title":"Postcardiopulmonary bypass lung edema. A preventable complication?","volume":"103","author":"Louagie\n \nY","year":"1993;"},{"issue":"(2)","key":"CIT0005","series-title":"Indian J Surg","first-page":"174\u20136","article-title":"Reexpansion pulmonary edema","volume":"74","author":"Chakraborty\n \nPP","year":"2012;"},{"issue":"(3)","key":"CIT0006","series-title":"Indian J Crit Care Med","first-page":"343\u20135","article-title":"Re-expansion pulmonary edema-a rare entity: a thin line between pulmonary and cardiac decompensation","volume":"25","author":"Sarna\n \nR","year":"2021;"},{"issue":"(6)","key":"CIT0007","series-title":"J Thorac Cardiovasc Surg","first-page":"868\u201375","article-title":"Fulminating noncardiogenic pulmonary edema. A newly recognized hazard during cardiac operations","volume":"80","author":"Culliford\n \nAT","year":"1980;"},{"issue":"(4)","key":"CIT0008","series-title":"Ann Thorac Surg","first-page":"462\u20134","article-title":"Venovenous extracorporeal membrane oxygenation for noncardiogenic pulmonary edema after coronary bypass surgery","volume":"46","author":"Katz\n \nNM","year":"1988;"},{"issue":"(6)","key":"CIT0009","series-title":"Kyobu Geka","first-page":"417\u201322","article-title":"[Unilateral pulmonary edema during aortic valve replacement through median sternotomy]","volume":"73","author":"Toyama\n \nM","year":"2020;"},{"key":"CIT0010","first-page":"525\u20137","article-title":"Severe re-expansion pulmonary edema after conventional cardiac surgery: identification and management","volume":"34","author":"Vardas\n \nPN","year":"2019;"},{"issue":"(5)","key":"CIT0011","series-title":"Eur J Cardiothorac Surg","first-page":"721\u20137","article-title":"The role of tissue reperfusion in the reexpansion injury of the lungs","volume":"22","author":"Sivrikoz\n \nMC","year":"2002;"},{"issue":"(4)","key":"CIT0012","series-title":"Ann Thorac Cardiovasc Surg","first-page":"205\u20139","article-title":"Reexpansion pulmonary edema","volume":"14","author":"Sohara\n \nY","year":"2008;"},{"issue":"(3)","key":"CIT0013","series-title":"Am J Med","first-page":"497\u2013500","article-title":"Evidence for increased permeability in reexpansion pulmonary edema","volume":"71","author":"Sprung\n \nCL","year":"1981;"},{"issue":"(1)","key":"CIT0014","series-title":"Ann Thorac Surg","first-page":"115\u201322","article-title":"Unilateral postoperative pulmonary edema after: a case-control study","volume":"99","author":"Tutschka\n \nMP","year":"2015;"},{"issue":"(2)","key":"CIT0015","series-title":"J Thorac Cardiovasc Surg","first-page":"237\u201344","article-title":"Cardiopulmonary bypass reduces pulmonary surfactant activity in infants","volume":"118","author":"Griese\n \nM","year":"1999;"},{"issue":"(6)","key":"CIT0016","series-title":"J Cardiothorac Vasc Anesth","first-page":"814\u201322","article-title":"Cardiopulmonary bypass duration is an independent predictor of morbidity and mortality after cardiac surgery","volume":"22","author":"Salis\n \nS","year":"2008;"},{"issue":"(3)","key":"CIT0017","series-title":"J Tehran Heart Cent","first-page":"128\u201331","article-title":"The effect of low tidal volume ventilation during cardiopulmonary bypass on postoperative pulmonary function","volume":"5","author":"Davoudi\n \nM","year":"2010;"},{"issue":"(5)","key":"CIT0018","series-title":"Braz J Cardiovasc Surg","first-page":"694\u2013701","article-title":"The effect of low tidal volume ventilation on inflammatory cytokines during cardiopulmonary bypass","volume":"37","author":"Kank\u0131l\u0131\u00e7\n \nN","year":"2022;"},{"issue":"(4)","key":"CIT0019","series-title":"Perfusion","first-page":"205\u201310","article-title":"Clinical relevance of ventilation during cardiopulmonary bypass in the prevention of postoperative lung dysfunction","volume":"25","author":"Gagnon\n \nJ","year":"2010;"},{"issue":"(5)","key":"CIT0020","series-title":"Chest","first-page":"1843\u201353","article-title":"Low tidal volume mechanical ventilation against no ventilation during cardiopulmonary bypass in heart surgery (MECANO): a randomized controlled trial","volume":"159","author":"Nguyen\n \nLS","year":"2021;"},{"issue":"(1)","key":"CIT0021","series-title":"J Cardiothorac Surg","first-page":"319","article-title":"Effect of ventilation strategy during cardiopulmonary bypass on postoperative pulmonary complications after cardiac surgery: a randomized clinical trial","volume":"16","author":"Zhang\n \nMQ","year":"2021;"}],"container-title":["Qatar Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.qscience.com\/view\/journals\/qmj\/2025\/2\/article-61.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.qscience.com\/downloadpdf\/journals\/qmj\/2025\/2\/article-61.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.qscience.com\/downloadpdf\/journals\/qmj\/2025\/2\/article-61.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:17:19Z","timestamp":1777310239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.qscience.com\/view\/journals\/qmj\/2025\/2\/article-61.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":42,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5339\/qmj.2025.61","relation":{},"ISSN":["2227-0426"],"issn-type":[{"value":"2227-0426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}