{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:57:21Z","timestamp":1782395841540,"version":"3.54.5"},"reference-count":36,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Lung cancer is a leading cause of cancer-related mortality globally, often presenting with diverse and challenging manifestations. This case report discusses an unusual presentation of epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) initially mimicking tuberculosis (TB), complicated by pituitary involvement.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    A 30-year-old female presented with respiratory symptoms and systemic complaints, initially suggestive of miliary TB. Further investigations revealed metastatic lung adenocarcinoma with pituitary metastasis, causing diabetes insipidus, hyperprolactinemia, adrenal insufficiency, and hypothyroidism. Treatment with targeted therapy involving osimertinib resulted in clinical improvement.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This case underscores the diagnostic challenges posed by atypical presentations of lung cancer, which can masquerade as infectious diseases like TB. The presence of pituitary metastasis further complicates the clinical picture, emphasizing the importance of considering rare metastatic sites in the differential diagnosis of lung adenocarcinoma. Timely recognition and appropriate management are crucial for optimizing outcomes in such complex cases, highlighting the need for a multidisciplinary approach in oncological and endocrine care.\n                  <\/jats:p>","DOI":"10.5339\/qmj.2025.64","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:30:48Z","timestamp":1750141848000},"source":"Crossref","is-referenced-by-count":1,"title":["Endocrine manifestations of lung adenocarcinoma with epidermal growth factor receptor mutation mimicking tuberculosis: A case report and literature review"],"prefix":"10.5339","volume":"2025","author":[{"given":"Lara","family":"Arafsha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaza A.","family":"Samargandy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-5069","authenticated-orcid":true,"given":"Anas S.","family":"Alyazidi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia*Correspondence: Anas S. Alyazidi alyazidi.anas@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3277","reference":[{"issue":"(4):","key":"CIT0001","series-title":"Int J Cancer","first-page":"778\u2013789","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay\n \nJ","year":"2021;"},{"key":"CIT0002","series-title":"Respir Med Case Rep","first-page":"100881","article-title":"Unusual presentation of primary lung adenocarcinoma mimicking pneumonia: case report and literature review","volume":"28","author":"Daoud\n \nA","year":"2019;"},{"issue":"(1):","key":"CIT0003","series-title":"J Fungi","first-page":"29","article-title":"Examining miliary disease etiology in a coccidioides-endemic center: a retrospective cohort study","volume":"10","author":"Scott\n \nAM","year":"2024;"},{"issue":"(3)","key":"CIT0004","series-title":"Clin Case Rep","article-title":"Pulmonary adenocarcinoma mimicking miliary tuberculosis in a 20-year-old man: a clinical case report","volume":"11","author":"Seifi\n \nA","year":"2023;"},{"issue":"(1):","key":"CIT0005","series-title":"Endocrinol Diabetes Metab Case Rep","first-page":"1\u20136","article-title":"Multiple endocrinological failures as a clinical presentation of a metastatic lung adenocarcinoma","volume":"2020","author":"Ach\n \nT","year":"2020;"},{"issue":"(5):","key":"CIT0006","series-title":"Glob Adv Heal Med","first-page":"38","article-title":"The CARE guidelines: consensus-based clinical case reporting guideline development","volume":"2","author":"Gagnier\n \nJJ","year":"2013;"},{"issue":"(13):","key":"CIT0007","series-title":"Chin Med J (Engl)","first-page":"1583","article-title":"Global burden and trends of lung cancer incidence and mortality","volume":"136","author":"Li\n \nC","year":"2023;"},{"issue":"(7):","key":"CIT0008","series-title":"Med J Aust","first-page":"334\u20136","article-title":"Lung cancer: progress with prognosis and the changing state of play","volume":"216","author":"Brims\n \nFJ","year":"2022;"},{"key":"CIT0009","series-title":"BMJ","first-page":"q2400","article-title":"Tuberculosis: disruption to health services from pandemic has allowed cases to reach record levels worldwide","volume":"387","author":"Taylor\n \nL","year":"2024;"},{"issue":"(8)","key":"CIT0010","series-title":"Cureus","article-title":"Miliary tuberculosis in a young patient? 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