{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:53:45Z","timestamp":1777312425258,"version":"3.51.4"},"reference-count":30,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"\n Introduction:<\/jats:bold>\n Cyberlindnera fabianii<\/jats:italic>\n is an uncommon opportunistic yeast increasingly recognized as a cause of invasive fungal infections, particularly in immunocompromised patients and those with indwelling medical devices. Clinical experience remains limited, with most published cases involving neonates or adults with significant comorbidities.\n <\/jats:p>\n \n Case Presentation:<\/jats:bold>\n We report a case of\n C<\/jats:italic>\n .\n fabianii<\/jats:italic>\n fungemia in a 26-year-old man with end-stage renal disease on maintenance hemodialysis via a long-term tunneled catheter. The patient presented with fever following dialysis and was found to have leukocytosis and elevated inflammatory markers. Blood cultures from both peripheral and catheter sites grew yeast after 48 hours. Empiric antibacterial therapy was initiated, and the hemodialysis catheter was removed. Antifungal treatment with anidulafungin was started, leading to clinical improvement. Species identification was achieved using matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI-TOF MS), which revealed\n C<\/jats:italic>\n .\n fabianii<\/jats:italic>\n . Antifungal susceptibility testing demonstrated low minimum inhibitory concentrations (MICs) for echinocandins and variable susceptibility to azoles. The patient completed a 14-day course of anidulafungin with full recovery.\n <\/jats:p>\n \n Discussion:<\/jats:bold>\n This case underscores the importance of accurate identification of rare yeasts such as\n C<\/jats:italic>\n .\n fabianii<\/jats:italic>\n , which may be misidentified as other less pathogenic species. MALDI-TOF MS and molecular diagnostics are critical tools for early detection. Due to its potential for azole resistance and biofilm formation, echinocandins appear to be an effective treatment option. Prompt catheter removal and appropriate antifungal therapy were pivotal to the patient\u2019s successful outcome.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n C<\/jats:italic>\n .\n fabianii<\/jats:italic>\n should be considered in patients with fungemia and risk factors for invasive candidiasis, especially when initial identification is inconclusive. Awareness of this emerging pathogen and its management is essential to ensure timely intervention and improve clinical outcomes.\n <\/jats:p>","DOI":"10.5339\/qmj.2025.90","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:30:37Z","timestamp":1758090637000},"source":"Crossref","is-referenced-by-count":0,"title":["Central line-associated Cyberlindnera fabianii fungemia: A case report and review of diagnostic and therapeutic challenges"],"prefix":"10.5339","volume":"2025","author":[{"given":"Sreethish","family":"Sasi","sequence":"first","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gawahir A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husam","family":"Salah","sequence":"additional","affiliation":[{"name":"Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Goravey","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna Al","family":"Maslamani","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar"},{"name":"College of Medicine, Qatar University, Doha, Qatar*Correspondence: Sreethish Sasi ssasi7@hamad.qa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3277","reference":[{"issue":"(3):","key":"CIT0001","series-title":"J Microbiol Immunol Infect","first-page":"644\u20136","article-title":"Cyberlindnera fabianii fungemia complicating psoas muscle abscess successfully treated by surgical drainage and echinocandin therapy","volume":"56","author":"Wang\n \nCH","year":"2023"},{"issue":"(6):","key":"CIT0002","series-title":"Med Mycol","first-page":"601\u20135","article-title":"A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment","volume":"46","author":"Hamal\n \nP","year":"2008"},{"issue":"(3):","key":"CIT0003","series-title":"Ann Clin Microbiol","first-page":"94\u201397","article-title":"Successful treatment of fungemia caused by Cyberlindnera fabianii with anidulafungin: a case report","volume":"18","author":"Lee\n \nJI","year":"2015;"},{"issue":"(5):","key":"CIT0004","series-title":"Int J Hematol","first-page":"592\u20135","article-title":"Fatal Cyberlindnera fabianii fungemia in a patient with mixed phenotype acute leukemia after umbilical cord blood transplantation","volume":"103","author":"Katagiri\n \nS","year":"2016"},{"issue":"(6):","key":"CIT0005","series-title":"Infection","first-page":"921\u20134","article-title":"Peritonitis in a neonate due to Cyberlindnera fabianii, an ascomycetic yeast","volume":"45","author":"Hof\n \nH","year":"2017"},{"issue":"(1):","key":"CIT0006","series-title":"Mycoses","first-page":"51\u201361","article-title":"Cyberlindnera fabianii fungaemia outbreak in preterm neonates in Kuwait and literature review","volume":"62","author":"Al-Sweih\n \nN","year":"2019"},{"issue":"(4):","key":"CIT0007","series-title":"J Infect Chemother","first-page":"102662","article-title":"Central venous access Port-Related blood stream infection caused by Cyberlindnera fabianii : a 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antirheumatic drugs in Qatar","volume":"13","author":"Sasi\n \nS","year":"2025"},{"issue":"(4):","key":"CIT0011","first-page":"e203","article-title":"Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM [published correction appears in Lancet Infect Dis","volume":"25","author":"Cornely\n \nOA","year":"2025"},{"issue":"(4):","key":"CIT0012","series-title":"Mycobiology","first-page":"449\u201356","article-title":"Identification and antifungal susceptibility profiles of Cyberlindnera fabianii in Korea","volume":"47","author":"Park\n \nJH","year":"2019"},{"issue":"(4):","key":"CIT0013","series-title":"Clin Infect Dis","first-page":"e1\u2013e50","article-title":"Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America","volume":"62","author":"Pappas\n \nPG","year":"2016"},{"issue":"(4):","key":"CIT0014","first-page":"551","article-title":"KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update [published correction appears in Am J Kidney Dis","volume":"77","author":"Lok\n \nCE","year":"2021"},{"issue":"(8):","key":"CIT0015","series-title":"J Vasc Interv Radiol","first-page":"997\u20131007","article-title":"Guidelines for the prevention of intravascular catheter-related infections: recommendations relevant to interventional radiology for venous catheter placement and maintenance","volume":"23","author":"Miller\n \nDL","year":"2012"},{"issue":"(3):","key":"CIT0001","series-title":"J Microbiol Immunol Infect","first-page":"644\u20136","article-title":"Cyberlindnera fabianii fungemia complicating psoas muscle abscess successfully treated by surgical drainage and echinocandin therapy","volume":"56","author":"Wang\n \nCH","year":"2023"},{"issue":"(6):","key":"CIT0002","series-title":"Med Mycol","first-page":"601\u20135","article-title":"A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and 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\nH","year":"2017"},{"issue":"(1):","key":"CIT0006","series-title":"Mycoses","first-page":"51\u201361","article-title":"Cyberlindnera fabianii fungaemia outbreak in preterm neonates in Kuwait and literature review","volume":"62","author":"Al-Sweih\n \nN","year":"2019"},{"issue":"(4):","key":"CIT0007","series-title":"J Infect Chemother","first-page":"102662","article-title":"Central venous access Port-Related blood stream infection caused by Cyberlindnera fabianii : a case report and literature review","volume":"31","author":"Kawasaki\n \nK","year":"2025"},{"issue":"(7):","key":"CIT0008","series-title":"Med Mycol","first-page":"833\u201340","article-title":"Unequivocal identification of an underestimated opportunistic yeast species, Cyberlindnera fabianii, and its close relatives using a dual-function PCR and literature review of published cases","volume":"57","author":"Arastehfar\n \nA","year":"2019"},{"issue":"(3):","key":"CIT0009","series-title":"J Mycol Med","first-page":"101410","article-title":"Four uncommon clinical fungi, Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii and Wickerhamomyces anomalus, isolated in superficial samples from C\u00f4te d\u2019Ivoire","volume":"33","author":"Ira\n \nAVB","year":"2023"},{"issue":"(4):","key":"CIT0010","series-title":"Immun Inflamm Dis","first-page":"e70195","article-title":"Risk of serious infections in patients treated with biologic or targeted-synthetic disease modifying antirheumatic drugs in Qatar","volume":"13","author":"Sasi\n \nS","year":"2025"},{"issue":"(4):","key":"CIT0011","first-page":"e203","article-title":"Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM [published correction appears in Lancet Infect Dis","volume":"25","author":"Cornely\n \nOA","year":"2025"},{"issue":"(4):","key":"CIT0012","series-title":"Mycobiology","first-page":"449\u201356","article-title":"Identification and 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