{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:53:22Z","timestamp":1781697202022,"version":"3.54.5"},"reference-count":46,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background and objective:<\/jats:bold>\n                    Osteoporosis poses significant risks to skeletal health and dental treatment outcomes. This study evaluated the diagnostic potential of cone beam computed tomography (CBCT) voxel values and radiomorphometric analysis in identifying low bone mineral density (BMD), exploring their correlation with calcaneal quantitative ultrasound (QUS) and serum biomarkers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A cross-sectional study was conducted on 86 participants aged over 40 years. QUS of the calcaneus was utilized to classify subjects into normal or osteopenic\/osteoporosis groups. CBCT-derived voxel values (cortical and cancellous) and radiomorphometric indices were recorded alongside serum calcium and 25(OH) vitamin D levels. Statistical analyses included Pearson\u2019s\/Spearman\u2019s correlations and t-tests to compare groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Participants with normal QUS T-scores exhibited significantly higher CBCT cortical (855.63 \u00b1 71.38) and cancellous (439.90 \u00b1 85.61) voxel values compared to osteoporotic individuals (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Strong positive correlations were found between QUS T-scores and CBCT voxel values (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.766 for cortical;\n                    <jats:italic>r<\/jats:italic>\n                    = 0.789 for cancellous), as well as with serum vitamin D (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Serum calcium showed a weaker but significant correlation. CBCT-derived radiomorphometric indices did not significantly correlate with QUS T-scores. However, a strong negative correlation was observed between the qualitative computed tomography cortical index (CTCI) grading and QUS T-score (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Interpretation and Conclusion:<\/jats:bold>\n                    CBCT voxel values and CTCI strongly correlate with QUS measurements and vitamin D levels, offering superior diagnostic utility compared to standard morphometric indices. These metrics may serve as effective adjunctive tools for opportunistic osteoporosis screening in dental settings, facilitating early diagnosis and risk management.\n                  <\/jats:p>","DOI":"10.5339\/qmj.2026.31","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:09:25Z","timestamp":1781694565000},"source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic accuracy of CBCT voxel values and calcaneal QUS in detecting low bone mineral density and their association with serum biomarkers"],"prefix":"10.5339","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-1935","authenticated-orcid":true,"given":"Neetha","family":"Harisha","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9716-2183","authenticated-orcid":true,"given":"Shailesh","family":"Mane","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3852-375X","authenticated-orcid":true,"given":"Amritha","family":"C","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwari G.","family":"Annigeri","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, 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\n\nhttps:\/\/doi.org\/10.1007\/s11914-012-0114-3"},{"issue":"11:","key":"B18","series-title":"Osteoporos Int","first-page":"2829","article-title":"Bone health in healthy Indian population aged 50 years and above","volume":"22","author":"Marwaha\n \nRK","year":"2011","unstructured":"Marwaha\n \nRK\n\n, \n\nTandon\n \nN\n\n, \n\nGarg\n \nMK\n\n, \n\nKanwar\n \nR\n\n, \n\nNarang\n \nA\n\n, \n\nSastry\n \nA\n\n, \n\nSaberwal\n \nA\n\n, \n\nBhadra\n \nK\n\n, \n\nMithal\n \nA\n\n\n. \nBone health in healthy Indian population aged 50 years and above\n. \nOsteoporos Int\n. \n2011\nNov;\n22\n11:\n2829\n36\n. \n\nhttps:\/\/doi.org\/10.1007\/s00198-010-1507-8\n\n. \nEpub 2011 Jan 27\n."},{"issue":"1:","key":"B19","series-title":"Dentomaxillofac Radiol","first-page":"20140238","article-title":"CBCT-based bone quality assessment: are Hounsfield units applicable? 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