{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:54:29Z","timestamp":1782392069897,"version":"3.54.5"},"reference-count":14,"publisher":"Hamad bin Khalifa University Press (HBKU Press)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of renal dysfunction and is increasingly being reclassified into immune complex-mediated and complement-mediated forms. Infections, particularly in endemic regions, may act as disease triggers. Pregnancy further complicates renal pathology through physiological and immunological changes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case presentation<\/jats:bold>\n                    : We describe a 22-year-old pregnant woman presenting with generalized edema, proteinuria, and cola-colored urine. Renal biopsy revealed diffuse endocapillary proliferation with mesangial and capillary wall C3 deposition, consistent with immune complex-mediated MPGN, with ultrastructural features suggestive of dense deposit disease (DDD). During hospitalization, she developed fever, papilledema, and neurological deficits. Blood cultures grew\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhi, and urine cultures isolated vancomycin-resistant\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    . Targeted antimicrobial therapy improved systemic symptoms, while cyclosporine was initiated for persistent proteinuria.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion<\/jats:bold>\n                    : This case report illustrates an atypical presentation of DDD during pregnancy, potentially triggered by typhoid fever and complicated by neurological involvement. It underscores the diagnostic challenges in resource-limited settings and the complex interplay among infection, complement dysregulation, and gestation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : This case report illustrates an atypical presentation of MPGN during pregnancy, triggered by typhoid fever and complicated by multidrug-resistant infection and neurological involvement. The patient\u2019s renal and neurological symptoms improved with antibiotics and supportive care; however, the pregnancy resulted in intrauterine fetal demise at 28 weeks. Early recognition and multidisciplinary care were pivotal to maternal stabilization and fetal management.\n                  <\/jats:p>","DOI":"10.5339\/qmj.2026.45","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:42:09Z","timestamp":1782391329000},"source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy-associated dense deposit disease with neurological complications caused by Salmonella Typhi: A case report"],"prefix":"10.5339","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2674-2508","authenticated-orcid":true,"given":"Sidra","family":"German","sequence":"first","affiliation":[{"name":"Department of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-181X","authenticated-orcid":true,"given":"Daniya","family":"Tarique","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5802-7036","authenticated-orcid":true,"given":"Tajammul","family":"Waqar","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0471-4585","authenticated-orcid":true,"given":"Sajid Islam","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8476-0734","authenticated-orcid":true,"given":"Huda","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sindh Institute of Urology and 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