{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T05:48:40Z","timestamp":1675316920332},"reference-count":0,"publisher":"World Health Organization, Western Pacific Regional Office","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WPSAR"],"published-print":{"date-parts":[[2022,7,22]]},"abstract":"<jats:p>Objective: Differences in clinical manifestations between strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. This retrospective descriptive study compares the clinical and demographic characteristics of all confirmed coronavirus disease (COVID-19) cases admitted to the National Isolation Centre (NIC) in the first wave and at the beginning of the second wave of the pandemic in Brunei Darussalam.  Methods: All COVID-19 cases admitted to the NIC between 9 March and 6 May 2020 (first wave) and 7\u201317 August 2021 (second wave) were included. Data were obtained from NIC databases and case characteristics compared using Student\u2019s t-tests and chi-squared tests, as appropriate.  Results: Cases from the first wave were significantly older than those from the second wave (mean 37.2 vs 29.7 years, P&lt;0.001), and a higher proportion reported comorbidities (30.5% vs 20.3%, P=0.019). Cases from the second wave were more likely to be symptomatic at admission (77.7% vs 63.1%, P&lt;0.001), with a higher proportion reporting cough, anosmia, sore throat and ageusia\/dysgeusia; however, myalgia and nausea\/vomiting were more common among symptomatic first wave cases (all P&lt;0.05). There was no difference in the mean number of reported symptoms (2.6 vs 2.4, P=0.890).  Discussion: Our study showed clear differences in the profile of COVID-19 cases in Brunei Darussalam between the first and second waves, reflecting a shift in the predominating SARS-CoV-2 strain. Awareness of changes in COVID-19 disease manifestation can help guide adjustments to management policies such as duration of isolation, testing strategies, and criteria for admission and treatment.<\/jats:p>","DOI":"10.5365\/wpsar.2022.13.3.925","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T09:22:09Z","timestamp":1675243329000},"page":"34-40","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and demographic characteristics of COVID-19 cases in Brunei Darussalam: comparison between the first and second waves, 2020 and 2021"],"prefix":"10.5365","volume":"13","author":[{"given":"Muhammad","family":"Umer Malik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Syafiq Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui Lin","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosmonaliza","family":"Asli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babu Ivan","family":"Mani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nooraffizan","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie Riamiza","family":"Momin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Ann","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee Fui","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vui Heng","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3383","published-online":{"date-parts":[[2022,7,22]]},"container-title":["Western Pacific Surveillance and Response Journal"],"original-title":[],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T09:22:17Z","timestamp":1675243337000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.wpro.who.int\/ojs\/index.php\/wpsar\/article\/view\/925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,7,22]]},"published-print":{"date-parts":[[2022,7,22]]}},"URL":"https:\/\/doi.org\/10.5365\/wpsar.2022.13.3.925","relation":{},"ISSN":["2094-7321","2094-7313"],"issn-type":[{"value":"2094-7321","type":"print"},{"value":"2094-7313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]}}}