{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T14:46:29Z","timestamp":1665413189474},"reference-count":0,"publisher":"POLEMOS S.A.","issue":"157","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vertex Rev Arg Psiquiatr"],"abstract":"<jats:p>Los tratamientos farmacol\u00f3gicos aprobados para la enfermedad de Alzheimer (EA) son sintom\u00e1ticos y no modifican el curso de la enfermedad. Estos incluyen inhibidores de la acetilcolinesterasa (IACE) y el antagonista del receptor de N-metil-D- aspartato, memantina. Estos medicamentos fueron aprobados para la demencia de tipo Alzheimer (DTA) hace unos 20 a\u00f1os, bas\u00e1ndose en ensayos cl\u00ednicos centrados en la presentaci\u00f3n cl\u00ednica amn\u00e9sica de la EA sin considerar biomarcadores o presentaciones cl\u00ednicas at\u00edpicas de EA. Los nuevos biomarcadores que detectan amiloide y neurodegeneraci\u00f3n nos han permitido evaluar cambios patol\u00f3gicos compatibles con la EA. Estos nuevos avances desde la perspectiva de los biomarcadores y cl\u00ednicos han llevado a una actualizaci\u00f3n de\u00a0 los criterios diagn\u00f3sticos, pasando de criterios exclusivamente cl\u00ednicos a criterios h\u00edbridos: cl\u00ednicos y basados en marcadores. Estos biomarcadores facilitan el diagn\u00f3stico precoz de la EA y otras demencias; sin embargo, a veces generan desaf\u00edos y replanteos en relaci\u00f3n al tratamiento farmacol\u00f3gico adecuado. Ser\u00eda \u00fatil implementar ensayos cl\u00ednicos que eval\u00faen la eficacia de los f\u00e1rmacos aprobados para la enfermedad de Alzheimer, en su momento con criterios de\u00a0 demencia tipo Alzheimer en funci\u00f3n de los criterios diagn\u00f3sticos actuales (perfil cl\u00ednico y biomarcadores). Adem\u00e1s, la actualizaci\u00f3n de la indicaci\u00f3n de prescripci\u00f3n de IACE y memantina por parte de las autoridades regulatorias especificando con m\u00e1s detalle la poblaci\u00f3n objetivo ayudar\u00eda a prescribir el mejor tratamiento posible a los pacientes sin aumentar los riesgos.\u00a0<\/jats:p>","DOI":"10.53680\/vertex.v33i157.268","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T14:05:34Z","timestamp":1665410734000},"page":"62-65","source":"Crossref","is-referenced-by-count":0,"title":["\u00bfTratamos la demencia tipo Alzheimer o la enfermedad de Alzheimer?F\u00e1rmacos antidemenciales en la era de los biomarcadores"],"prefix":"10.53680","volume":"33","author":[{"given":"Guido","family":"Dorman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Appiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Rosario","family":"Chiesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Vallejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Bustin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31787","published-online":{"date-parts":[[2022,10,10]]},"container-title":["Vertex Revista Argentina de Psiquiatr\u00eda"],"original-title":[],"link":[{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/268\/213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/268\/213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T14:05:34Z","timestamp":1665410734000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/view\/268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":0,"journal-issue":{"issue":"157","published-online":{"date-parts":[[2022,10,10]]}},"URL":"https:\/\/doi.org\/10.53680\/vertex.v33i157.268","relation":{},"ISSN":["2718-904X","0327-6139"],"issn-type":[{"value":"2718-904X","type":"electronic"},{"value":"0327-6139","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,10]]}}}