{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T13:10:28Z","timestamp":1729429828755,"version":"3.27.0"},"reference-count":0,"publisher":"POLEMOS S.A.","issue":"165","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vertex Rev Arg Psiquiatr"],"abstract":"<jats:p>La encefalopat\u00eda traum\u00e1tica cr\u00f3nica es una enfermedad neurodegenerativa resultante de la acumulaci\u00f3n de numerosos traumatismos craneoencef\u00e1licos, para la cual no existe un diagn\u00f3stico en vida definitivo ni un tratamiento espec\u00edfico. Entre los factores de riesgo asociados se encuentran: la exposici\u00f3n a deportes de contacto que predisponen a traumatismos craneoencef\u00e1licos cl\u00ednicos y subcl\u00ednicos reiterados, la presencia de la apolipoprote\u00edna E4 y la edad. A escala microsc\u00f3pica, la lesi\u00f3n patognom\u00f3nica de la enfermedad implica agregados de prote\u00edna tau fosforilada en neuronas, con o sin astrocitos en forma de espina, en las profundidades del surco cortical alrededor de un peque\u00f1o vaso sangu\u00edneo, en lo profundo del par\u00e9nquima y con un patr\u00f3n irregular, que pueden estar acompa\u00f1ado en ocasiones de otros dep\u00f3sitos de prote\u00ednas anormales y prevalentes en otras entidades como placas de beta-amiloide, TDP-43 y\/o alfa-sinucle\u00edna. Desde el punto de vista cl\u00ednico se caracteriza por un curso lento e insidioso que se inicia con s\u00edntomas cognitivos leves, alteraciones del comportamiento y desregulaci\u00f3n emocional, y progresa hacia la aparici\u00f3n de s\u00edntomas motores tipo parkinsonianos y demencia. La \u00fanica forma de diagnosticar definitivamente la ETC es despu\u00e9s de la muerte, durante una autopsia del cerebro. A pesar de que se han propuesto criterios diagn\u00f3sticos prometedores, no est\u00e1n actualmente validados. Se est\u00e1n desarrollando biomarcadores que determinen en vida los cambios fisiopatol\u00f3gicos de la entidad sin necesidad de la biopsia.\u00a0<\/jats:p>","DOI":"10.53680\/vertex.v35i165.662","type":"journal-article","created":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T12:53:23Z","timestamp":1729428803000},"page":"74-84","source":"Crossref","is-referenced-by-count":0,"title":["Nuevos criterios diagn\u00f3sticos cl\u00ednico y neuropatol\u00f3gicos de la encefalopat\u00eda traum\u00e1tica cr\u00f3nica: una revisi\u00f3n narrativa"],"prefix":"10.53680","volume":"35","author":[{"given":"Mar\u00eda Julieta","family":"Russo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Salvat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"F. Allegri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo E.","family":"Sevlever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31787","published-online":{"date-parts":[[2024,10,20]]},"container-title":["Vertex Revista Argentina de Psiquiatr\u00eda"],"original-title":[],"link":[{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/662\/578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/662\/578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T12:53:24Z","timestamp":1729428804000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/view\/662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,20]]},"references-count":0,"journal-issue":{"issue":"165","published-online":{"date-parts":[[2024,10,20]]}},"URL":"https:\/\/doi.org\/10.53680\/vertex.v35i165.662","relation":{},"ISSN":["2718-904X","0327-6139"],"issn-type":[{"value":"2718-904X","type":"electronic"},{"value":"0327-6139","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,20]]}}}