{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T15:11:59Z","timestamp":1768144319992,"version":"3.49.0"},"reference-count":0,"publisher":"POLEMOS S.A.","issue":"170","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vertex Rev Arg Psiquiatr"],"abstract":"<jats:p>Este documento constituye la segunda parte del Primer Consenso Argentino sobre el Manejo de la Esquizofrenia y presenta una s\u00edntesis actualizada de la evidencia disponible sobre los aspectos cl\u00ednicos y diagn\u00f3sticos del trastorno en personas adultas. Siguiendo la metodolog\u00eda establecida en la primera parte del Consenso, el panel de expertos llev\u00f3 a cabo una revisi\u00f3n bibliogr\u00e1fica exhaustiva y un proceso sistem\u00e1tico de discusi\u00f3n yevaluaci\u00f3n cr\u00edtica de la informaci\u00f3n identificada. Como resultado de este trabajo colaborativo, se elabor\u00f3 esta segunda secci\u00f3n, destinada a orientar la pr\u00e1ctica cl\u00ednica a partir de un an\u00e1lisis riguroso de la literatura cient\u00edfica. Asimismo, durante las instancias deliberativas se decidi\u00f3 incorporar contenidos adicionales considerados especialmente relevantes para los equipos interdisciplinarios responsables del abordaje integral de los pacientes con esquizofrenia. En este sentido, el documento incluye desarrollos sobre aspectos cl\u00ednicos claves, criterios diagn\u00f3sticos y herramientas conceptuales que contribuyen a optimizar la evaluaci\u00f3n de esta patolog\u00eda. En l\u00ednea con lo anterior, en la segunda parte de este documento, se podr\u00e1n encontrar modelos de estadificaci\u00f3 en la esquizofrenia, las variantes sintom\u00e1ticas (s\u00edntomas negativos, cognitivos, positivos y afectivos), estadios iniciales de la esquizofrenia y ultra alto riesgo, primer episodio psic\u00f3tico, duraci\u00f3n de la psicosis no tratada y m\u00e9todos auxiliares de diagn\u00f3stico. Este trabajo colaborativo cont\u00f3 con la colaboraci\u00f3n de la Asociaci\u00f3n de Ayuda de Familiares de Personas con Esquizofrenia (AAFE).<\/jats:p>","DOI":"10.53680\/vertex.v36i170.947","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T15:01:21Z","timestamp":1768057281000},"page":"103-145","source":"Crossref","is-referenced-by-count":0,"title":["Primer Consenso Argentino para el Manejo de la Esquizofrenia: Segunda Parte. 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