{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:18:09Z","timestamp":1783711089716,"version":"3.55.0"},"reference-count":0,"publisher":"POLEMOS S.A.","issue":"172","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vertex Rev Arg Psiquiatr"],"abstract":"<jats:p>La anhedonia, tradicionalmente definida como la incapacidad de experimentar placer, fue introducida en 1897 por el fil\u00f3sofo y psic\u00f3logo franc\u00e9s Th\u00e9odule Armand Ribot. Si bien este t\u00e9rmino a\u00fan se utiliza, ha sufrido modificaciones conceptuales ya que la dicotom\u00eda de la descripci\u00f3n original resulta insuficiente para capturar la complejidad de sus componentes. La experiencia hed\u00f3nica es un proceso din\u00e1mico y c\u00edclico que parte de un estado con un rango de referencia individual, conocido como tono hed\u00f3nico, que determina la capacidad de cada individuo para experimentar placer y felicidad. En la actualidad, la anhedonia es considerada un constructo transdiagn\u00f3stico, multidimensional y din\u00e1mico constituido por m\u00faltiples atributos o valencias cuya combinaci\u00f3n determina una gran variedad de fenotipos comportamentales. Estos pueden estar alterados de manera transitoria o representar un rasgo m\u00e1s duradero. La presencia de anhedonia en los diferentes trastornos psicopatol\u00f3gicos se asocia a una mayor gravedad, peor pron\u00f3stico y el riesgo de suicidio. Por este motivo, es fundamental contar con tratamientos eficientes, tanto psicoterap\u00e9uticos y farmacol\u00f3gicos. El objetivo del trabajo fue, mediante una revisi\u00f3n narrativa, ofrecer una opini\u00f3n cl\u00ednica experta, a partir de una s\u00edntesis de la evidencia, sobre algunos fenotipos de la anhedonia y sus posibles tratamientos. A modo de ejemplo, se incluyeron tres vi\u00f1etas cl\u00ednicas ficcionadas.<\/jats:p>","DOI":"10.53680\/vertex.v37i172.1017","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:11:11Z","timestamp":1783710671000},"page":"49-71","source":"Crossref","is-referenced-by-count":0,"title":["Anhedonia como fen\u00f3meno transdiagn\u00f3stico: aproximaciones neurobiol\u00f3gicas, cl\u00ednicas y terap\u00e9uticas"],"prefix":"10.53680","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7938-4264","authenticated-orcid":false,"given":"Paula Mirabel","family":"R\u00e9vora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7242-6827","authenticated-orcid":false,"given":"Mario","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-6979","authenticated-orcid":false,"given":"Fernando","family":"Torrente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6477-9959","authenticated-orcid":false,"given":"Pedro Dami\u00e1n","family":"Gargoloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9977-3573","authenticated-orcid":false,"given":"Mar\u00eda Florencia","family":"Iveli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31787","published-online":{"date-parts":[[2026,7,10]]},"container-title":["Vertex Revista Argentina de Psiquiatr\u00eda"],"original-title":[],"link":[{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/1017\/782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/1017\/782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:11:11Z","timestamp":1783710671000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/view\/1017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":0,"journal-issue":{"issue":"172","published-online":{"date-parts":[[2026,7,10]]}},"URL":"https:\/\/doi.org\/10.53680\/vertex.v37i172.1017","relation":{},"ISSN":["2718-904X","0327-6139"],"issn-type":[{"value":"2718-904X","type":"electronic"},{"value":"0327-6139","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,10]]}}}