{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:54:24Z","timestamp":1791636864436,"version":"4.3.4"},"reference-count":0,"publisher":"POLEMOS S.A.","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vertex Rev Arg Psiquiatr"],"abstract":"<jats:p>Objetivo: a pesar de ser un f\u00e1rmaco altamente eficaz para el tratamiento de la esquizofrenia resistente al tratamiento (ERT), la clozapina contin\u00faa siendo subutilizada. Este estudio tiene como objetivo evaluar los patrones de prescripci\u00f3n de Clozapina en pacientes ambulatorios de un hospital especializado en psiquiatr\u00eda de Argentina. M\u00e9todos: este estudio observacional descriptivo retrospectivo de corte transversal incluy\u00f3 pacientes adultos con diagn\u00f3stico de esquizofrenia que realizan tratamiento ambulatorio en nuestra instituci\u00f3n. Los datos fueron recolectados mediante la revisi\u00f3n de historias cl\u00ednicas en el per\u00edodo noviembre 2024-enero 2025. Los an\u00e1lisis estad\u00edsticos incluyeron estad\u00edsticas descriptivas, pruebas t pareadas, correlaciones de Pearson y regresi\u00f3n m\u00faltiple. Resultados: la muestra incluy\u00f3 199 pacientes y tuvo una edad media de 36 a\u00f1os (DE: 6,6). El 75,4 % recib\u00eda medicaci\u00f3n concomitante; el uso previo de antipsic\u00f3ticos inyectables de acci\u00f3n prolongada (IAP) fue bajo (8 %), mientras que la polifarmacia antipsic\u00f3tica fue frecuente (30,6 %). El tiempo medio entre el diagn\u00f3stico de esquizofrenia y el inicio del tratamiento con clozapina fue superior a cinco a\u00f1os (266,47 semanas, DE: 270,4), con un promedio de 3,17 ensayos previos adecuados con antipsic\u00f3ticos (DE: 1,53). Las hospitalizaciones disminuyeron significativamente despu\u00e9s del inicio del tratamiento con clozapina (cambio medio: 1,74, DE: 1,14; tama\u00f1o del efecto grande, d = 1,09). Conclusiones: los hallazgos obtenidos indican que la clozapina contin\u00faa siendo subutilizada en nuestro medio y resaltan la importancia de iniciarla de manera m\u00e1s temprana para reducir las tasas de hospitalizaci\u00f3n y mejorar los resultados cl\u00ednicos.<\/jats:p>","DOI":"10.53680\/vertex.v37i173.1062","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:31:32Z","timestamp":1791635492000},"page":"30-37","source":"Crossref","is-referenced-by-count":0,"title":["Clozapina y esquizofrenia resistente: patrones de prescripci\u00f3n en un hospital neuropsiqui\u00e1trico de la Ciudad de Buenos Aires"],"prefix":"10.53680","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-628X","authenticated-orcid":false,"given":"Julieta","family":"Ram\u00edrez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1629-6894","authenticated-orcid":false,"given":"Mar\u00eda Delfina","family":"Tavella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7748-7072","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2611-7648","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Weisbrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7613-846X","authenticated-orcid":false,"given":"Guillermo J.","family":"H\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-5623","authenticated-orcid":false,"given":"Daniel","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8606-397X","authenticated-orcid":false,"given":"Nora S.","family":"Crespi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-2009","authenticated-orcid":false,"given":"Ricardo","family":"Corral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31787","published-online":{"date-parts":[[2026,10,10]]},"container-title":["Vertex Revista Argentina de Psiquiatr\u00eda"],"original-title":[],"link":[{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/1062\/824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/1062\/824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:31:32Z","timestamp":1791635492000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/view\/1062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.53680\/vertex.v37i173.1062","relation":{},"ISSN":["2718-904X","0327-6139"],"issn-type":[{"value":"2718-904X","type":"electronic"},{"value":"0327-6139","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,10]]}}}