{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:53:56Z","timestamp":1791636836930,"version":"4.3.4"},"reference-count":0,"publisher":"POLEMOS S.A.","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vertex Rev Arg Psiquiatr"],"abstract":"<jats:p>En las \u00faltimas d\u00e9cadas, el estudio del conectoma humano \u2013mapa integral de las conexiones neuronales del cerebro\u2013 ha redefinido la comprensi\u00f3n del trastorno depresivo mayor (TDM) como un espectro de alteraciones funcionales y estructurales en redes cerebrales espec\u00edficas. Esta revisi\u00f3n explora evidencia sobre patrones de conectividad funcional en el TDM, destacando la implicancia de redes como la red neuronal por defecto (RND), la red frontoparietal (RFP), la red de saliencia (RS) y los circuitos de recompensa. Se analizan patrones detectados mediante resonancia magn\u00e9tica funcional (RMf) y su potencial como biomarcadores para predecir respuesta a las intervenciones que hoy forman parte de las gu\u00edas cl\u00ednicas y constituyen el arsenal habitual en la pr\u00e1ctica, como la psicoterapia, los antidepresivos de primera l\u00ednea (ISRS), la estimulaci\u00f3n magn\u00e9tica transcraneal (EMT), la terapia electroconvulsiva (TEC) y la ketamina a dosis subanest\u00e9sicas. Para ello, realizamos una revisi\u00f3n narrativa integrativa de la literatura cient\u00edfica, seleccionando art\u00edculos por relevancia cl\u00ednica y calidad metodol\u00f3gica (GRADE), incluyendo metaan\u00e1lisis, revisiones sistem\u00e1ticas y ensayos cl\u00ednicos aleatorizados. Estos hallazgos podr\u00edan generar un cambio de paradigma hacia una psiquiatr\u00eda de precisi\u00f3n, cada vez m\u00e1s centrada en la persona. Aunque persisten desaf\u00edos metodol\u00f3gicos que limitan su aplicaci\u00f3n cl\u00ednica, comprender el conectoma y su relaci\u00f3n con la patog\u00e9nesis del TDM es un paso fundamental hacia una verdadera atenci\u00f3n personalizada en salud mental.<\/jats:p>","DOI":"10.53680\/vertex.v37i173.1067","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:12:45Z","timestamp":1791634365000},"page":"78-87","source":"Crossref","is-referenced-by-count":0,"title":["Conectoma y depresi\u00f3n: hacia una psiquiatr\u00eda de precisi\u00f3n basada en redes cerebrales"],"prefix":"10.53680","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0180-8541","authenticated-orcid":false,"given":"Mar\u00eda Victoria","family":"Majul Conte Grand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0155-327X","authenticated-orcid":false,"given":"Micaela","family":"Dines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-1124","authenticated-orcid":false,"given":"Adriana V.","family":"Bulacia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31787","published-online":{"date-parts":[[2026,10,10]]},"container-title":["Vertex Revista Argentina de Psiquiatr\u00eda"],"original-title":[],"link":[{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/1067\/829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/download\/1067\/829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:12:46Z","timestamp":1791634366000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistavertex.com.ar\/ojs\/index.php\/vertex\/article\/view\/1067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.53680\/vertex.v37i173.1067","relation":{},"ISSN":["2718-904X","0327-6139"],"issn-type":[{"value":"2718-904X","type":"electronic"},{"value":"0327-6139","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,10]]}}}