{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:51:28Z","timestamp":1784206288308,"version":"3.55.0"},"reference-count":26,"publisher":"The Fukushima Society of Medical Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FJMS","Fukushima J. Med. Sci."],"published-print":{"date-parts":[[2019]]},"DOI":"10.5387\/fms.2019-21","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T22:06:48Z","timestamp":1569535608000},"page":"71-75","source":"Crossref","is-referenced-by-count":26,"title":["Gut and oral microbiota in autoimmune liver disease"],"prefix":"10.5387","volume":"65","author":[{"given":"Kazumichi","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Okai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3342","reference":[{"key":"1","unstructured":"1. Rai R, Saraswat VA, Dhiman RK. Gut microbiota: its role in hepatic encephalopathy. J Clin Exp Hepatol, <b>5<\/b>: 29-36, 2015."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, <i>et al.<\/i> A human gut microbial gene catalogue established by metagenomic sequencing. Nature, <b>464<\/b>: 59-65, 2010.","DOI":"10.1038\/nature08821"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hooper LV, Macpherson AJ. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol, <b>10<\/b>: 159-169, 2010.","DOI":"10.1038\/nri2710"},{"key":"4","unstructured":"4. Fraher MH, O\u2019Toole PW, Quigley EM. Techniques used to characterize the gut microbiota: a guide for the clinician. Nat Rev Gastroenterol Hepatol, <b>9<\/b>: 312-22, 2012."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Avila M, Ojcius DM and Yilmaz, O. The oral microbiota: living with a permanent guest, DNA Cell Biol, <b>28<\/b>: 405-411, 2009.","DOI":"10.1089\/dna.2009.0874"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Dewhirst, FE, Chen, T, Izard, J, Paster BJ, Tanner AC, Yu WH, <i>et al.<\/i> The human oral microbiome. J. Bacteriol, <b>192<\/b>: 5002-5017, 2010.","DOI":"10.1128\/JB.00542-10"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Curtis MA, Zenobia C. and Darveau RP. The relationship of the oral microbiotia to periodontal health and disease. Cell Host Microbe, <b>10<\/b>: 302-306, 2011.","DOI":"10.1016\/j.chom.2011.09.008"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Miyake S, Kim S, Suda W, Oshima K, Nakamura M, Matsuoka T, <i>et al.<\/i> Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters. PLoS One, <b>10<\/b>(9): e0137429, 2015. doi: 10.1371\/journal.pone.0137429. PMID: 26367776","DOI":"10.1371\/journal.pone.0137429"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, <i>et al.<\/i> Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A, <b>114<\/b>(40): 10719-10724, 2017. doi: 10.1073\/pnas.1711233114. PMID: 28893994","DOI":"10.1073\/pnas.1711233114"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Cekanaviciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, <i>et al.<\/i> Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc Natl Acad Sci U S A, <b>114<\/b>(40): 10713-10718, 2017. doi: 10.1073\/pnas.1711235114. PMID: 28893978","DOI":"10.1073\/pnas.1711235114"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Zhang X, Zhang D, Jia H, Feng Q, Wang D, Liang D, <i>et al.<\/i> The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med, <b>21<\/b>(8): 895-905, 2015. doi: 10.1038\/nm.3914. PMID: 26214836","DOI":"10.1038\/nm.3914"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Phillips R. Rheumatoid arthritis: Microbiome reflects status of RA and response to therapy. Nat Rev Rheumatol, <b>11<\/b>(9): 502, 2015. doi: 10.1038\/nrrheum.2015.109. PMID: 26241185","DOI":"10.1038\/nrrheum.2015.109"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Said HS, Suda W, Nakagome S, Chinen H, Oshima K, Kim S, <i>et al.<\/i> Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. DNA Res, <b>21<\/b>(1): 15-25, 2014. doi: 10.1093\/dnares\/dst037. PMID: 24013298","DOI":"10.1093\/dnares\/dst037"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Atarashi K, Suda W, Luo C, Kawaguchi T, Motoo I, Narushima S, <i>et al.<\/i> Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science, <b>358<\/b>(6361): 359-365, 2017. doi: 10.1126\/science.aan4526. PMID: 29051379","DOI":"10.1126\/science.aan4526"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Bajaj JS, Betrapally NS, Hylemon PB, Heuman DM, Daita K, White MB, <i>et al.<\/i> Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy. Hepatology, <b>62<\/b>(4): 1260-1271, 2015. doi: 10.1002\/hep.27819. PMID: 25820757","DOI":"10.1002\/hep.27819"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Krawitt EL. Autoimmune hepatitis. N Engl J Med, <b>334<\/b>: 897-903, 1996.","DOI":"10.1056\/NEJM199604043341406"},{"key":"17","unstructured":"17. Lin R, Zhou L, Zhang J, Wang B. Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis. Int J Clin Exp Pathol, <b>8<\/b>(5): 5153-5160, 2015. PMID: 26191211"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Yuksel M, Wang Y, Tai N, Peng J, Guo J, Beland K, <i>et al.<\/i> A novel \u201chumanized mouse\u201d model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology, <b>62<\/b>(5): 1536-1550, 2015. doi: 10.1002\/hep.27998. PMID: 26185095","DOI":"10.1002\/hep.27998"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Czaja AJ. Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis. World J Gastroenterol, <b>22<\/b>(42): 9257-9278, 2016. Review. PMID: 27895415","DOI":"10.3748\/wjg.v22.i42.9257"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Wei Y, Li Y, Yan L, Sun C, Miao Q, Wang Q, Xiao X, Lian M, Li B, Chen Y, Zhang J, Li Y, Huang B, Li Y, Cao Q, Fan Z, Chen X, Fang JY, Gershwin ME, Tang R, Ma X. Alterations of gut microbiome in autoimmune hepatitis. Gut. 2019. pii: gutjnl-2018-317836. doi: 10.1136\/gutjnl-2018-317836. [Epub ahead of print]","DOI":"10.1136\/gutjnl-2018-317836"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Abe K, Takahashi A, Fujita M, Imaizumi H, Hayashi M, Okai K, <i>et al.<\/i> Dysbiosis of oral microbiota and its association with salivary immunological biomarkers in autoimmune liver disease. PLoS One, <b>13<\/b>(7): e0198757, 2018 Jul 3.","DOI":"10.1371\/journal.pone.0198757"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, <i>et al.<\/i> Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity, <b>32<\/b>: 815-827, 2010. doi: 10.1016\/j.immuni.2010.06.001. PMID: 20620945.","DOI":"10.1016\/j.immuni.2010.06.001"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23. Shimizu J, Kubota T, Takada E, Takai K, Fujiwara N, Arimitsu N, <i>et al.<\/i> Bifidobacteria Abundance-Featured Gut Microbiota Compositional Change in Patients with Behcet\u2019s Disease. PLoS One, <b>11<\/b>: e0153746, 2016. doi: 10.1371\/journal.pone.0153746. eCollection 2016. PMID: 27105322","DOI":"10.1371\/journal.pone.0153746"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med, <b>353<\/b>: 1261-1273, 2005.","DOI":"10.1056\/NEJMra043898"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Selmi C, Bowlus CL, Gershwin ME, Coppel RL. Primary biliary cirrhosis. Lancet, <b>377<\/b>: 1600-1609, 2011.","DOI":"10.1016\/S0140-6736(10)61965-4"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Tang R, Wei Y, Li Y, Chen W, Chen H, Wang Q, Yang F, Miao Q, Xiao X, Zhang H, Lian M, Jiang X, Zhang J, Cao Q, Fan Z, Wu M, Qiu D, Fang JY, Ansari A, Gershwin ME, Ma X. Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy. Gut, <b>67<\/b>: 534-541, 2018.","DOI":"10.1136\/gutjnl-2016-313332"}],"container-title":["FUKUSHIMA JOURNAL OF MEDICAL SCIENCE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fms\/65\/3\/65_2019-21\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T12:56:36Z","timestamp":1611406596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fms\/65\/3\/65_2019-21\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.5387\/fms.2019-21","relation":{},"ISSN":["0016-2590","2185-4610"],"issn-type":[{"value":"0016-2590","type":"print"},{"value":"2185-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}