{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:38:17Z","timestamp":1793129897845,"version":"4.5.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R33AG086944 and P30 AG044281"],"award-info":[{"award-number":["R33AG086944 and P30 AG044281"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatr Gerontol Aging"],"abstract":"<jats:p>Objective: To identify the main Barriers and facilitators to deprescribing from the perspective of primary care pharmacists in Brazil. \nMethods: In this qualitative secondary analysis, we analyzed brief written responses collected during a training session on medication deprescribing. Data were elicited through a SWOT (Strengths, Weaknesses, Opportunities, and Threats)-based structured activity and analyzed using qualitative content analysis. Emerging categories were subsequently interpreted through the Theoretical Domains Framework. \nResults: Responses were categorized into barriers (related to healthcare professionals, service structure, patients, and the healthcare model) and facilitators (advances in evidence, benefits of deprescribing, availability of resources, management support, and favorable attitudes among professionals and patients). These categories were mapped to Theoretical Domains Framework domains, including Beliefs about Consequences, Environmental Context and Resources, Social Influences, and Social\/Professional Role and Identity. \nConclusion: Implementing deprescribing in Brazil faces challenges but prospects are also promising. Adopting interprofessional approaches, educating patients, involving management, and investing in resources to strengthen primary health care are essential to optimize clinical outcomes and reduce health-related costs.<\/jats:p>","DOI":"10.53886\/gga.e0000523_en","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:14:36Z","timestamp":1789150476000},"update-policy":"https:\/\/doi.org\/10.53886\/gga.crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Barriers and facilitators to deprescribing in primary care in Brazil: a qualitative study of pharmacists' perspectives mapped to the Theoretical Domains Framework"],"prefix":"10.1055","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2208-1169","authenticated-orcid":false,"given":"Milena Flores de","family":"Melo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-6158","authenticated-orcid":false,"given":"Priscila Ribeiro","family":"Castro","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-6176","authenticated-orcid":false,"given":"Rafael Mota","family":"Pinheiro","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xfp8v59","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade de Bras\u00edlia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-9480","authenticated-orcid":false,"given":"Michael Alan","family":"Steinman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-009X","authenticated-orcid":false,"given":"Patrick Alexander","family":"Wachholz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00987cb86","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Estadual Paulista (Unesp)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-7889","authenticated-orcid":false,"given":"Marcio Galv\u00e3o","family":"Oliveira","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Mangin D, Bahat G, Golomb BA, Mallery LH, Moorhouse P, Onder G, et al. International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): position statement and 10 recommendations for action. Drugs Aging. 2018;35(7):575-87. https:\/\/doi.org\/10.1007\/s40266-018-0554-2","DOI":"10.1007\/s40266-018-0554-2"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Woodward MC. Deprescribing: achieving better health outcomes for older people through reducing medications. J Pharm Pract Res. 2003;33(4):322-5. https:\/\/doi.org\/10.1002\/jppr2003334323","DOI":"10.1002\/jppr2003334323"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Payne RA, Abel GA, Avery AJ, Mercer SW, Roland MO. Is polypharmacy always hazardous? A retrospective cohort analysis using linked electronic health records from primary and secondary care. Br J Clin Pharmacol. 2014;77(6):1073-82. https:\/\/doi.org\/10.1111\/bcp.12292","DOI":"10.1111\/bcp.12292"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Arrais PSD, Barreto ML, Coelho HLL. Drug prescription and dispensing from the patient's perspective: a community-based study in Fortaleza, Cear\u00e1 State, Brazil. Cad Saude Publica. 2007;23(4):927-37. https:\/\/doi.org\/10.1590\/S0102-311X2007000400020","DOI":"10.1590\/S0102-311X2007000400020"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Busfield J. Assessing the overuse of medicines. Soc Sci Med. 2015;131:199-206. https:\/\/doi.org\/10.1016\/j.socscimed.2014.10.061","DOI":"10.1016\/j.socscimed.2014.10.061"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Wang R, Chen L, Fan L, Gao D, Liang Z, He J, et al. Incidence and effects of polypharmacy on clinical outcome among patients aged 80+: a five-year follow-up study. PLoS One. 2015;10(11):e0142123. https:\/\/doi.org\/10.1371\/journal.pone.0142123","DOI":"10.1371\/journal.pone.0142123"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Doherty AJ, Boland P, Reed J, Clegg AJ, Stephani AM, Williams NH, et al. Barriers and facilitators to deprescribing in primary care: a systematic review. BJGP Open. 2020;4(3):bjgpopen20X101096. https:\/\/doi.org\/10.3399\/bjgpopen20X101096","DOI":"10.3399\/bjgpopen20X101096"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Motter FR, Cantuaria NM, Lopes LC. Healthcare professionals' knowledge, attitudes and practices toward deprescribing: a protocol of cross-sectional study (Desmedica Study\u2013Brazil). BMJ Open. 2021;11(8):e044312. https:\/\/doi.org\/10.1136\/bmjopen-2020-044312","DOI":"10.1136\/bmjopen-2020-044312"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Cane J, O'Connor D, Michie S. Validation of the theoretical domains framework for use in behaviour change and implementation research. Implement Sci. 2012;7:37. https:\/\/doi.org\/10.1186\/1748-5908-7-37","DOI":"10.1186\/1748-5908-7-37"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Michie S, Johnston M, Abraham C, Lawton R, Parker D, Walker A, et al. Making psychological theory useful for implementing evidence based practice: a consensus approach. Qual Saf Health Care. 2005;14(1):26-33. https:\/\/doi.org\/10.1136\/qshc.2004.011155","DOI":"10.1136\/qshc.2004.011155"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19(6):349-57. https:\/\/doi.org\/10.1093\/intqhc\/mzm042","DOI":"10.1093\/intqhc\/mzm042"},{"key":"ref11","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria de Ci\u00eancias, Tecnologia, Inova\u00e7\u00e3o e Insumos Estrat\u00e9gicos em Sa\u00fade. Departamento de Assist\u00eancia Farmac\u00eautica e Insumos Estrat\u00e9gicos. Anais do VII Congresso Brasileiro sobre o Uso Racional de Medicamentos: desafios e perspectivas para o uso racional de medicamentos na pr\u00e1tica interprofissional. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2020."},{"key":"ref12","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria de Ci\u00eancia, Tecnologia, Inova\u00e7\u00e3o e Insumos Estrat\u00e9gicos em Sa\u00fade. Departamento de Assist\u00eancia Farmac\u00eautica e Insumos Estrat\u00e9gicos. Contribui\u00e7\u00f5es para a promo\u00e7\u00e3o do uso racional de medicamentos. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2021."},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Gomide M, Sch\u00fctz GE, Carvalho MAR, C\u00e2mara VM. Fortalezas, Oportunidades, Fraquezas e Amea\u00e7as (Matriz FOFA) de uma Comunidade Ribeirinha Sul-Amaz\u00f4nica na perspectiva da An\u00e1lise de Redes Sociais: aportes para a Aten\u00e7\u00e3o B\u00e1sica \u00e0 Sa\u00fade. Ci\u00eanc Sa\u00fade Colet. 2015;23(3):222-30. https:\/\/doi.org\/10.1590\/1414-462X201500030089","DOI":"10.1590\/1414-462X201500030089"},{"key":"ref14","unstructured":"Bardin L. Content analysis. Lisbon: Edi\u00e7\u00f5es 70; 2015."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Scott S, Twigg MJ, Clark A, Farrow C, May H, Patel M, et al. Development of a hospital deprescribing implementation framework: a focus group study with geriatricians and pharmacists. Age Ageing. 2020;49(1):102-10. https:\/\/doi.org\/10.1093\/ageing\/afz133","DOI":"10.1093\/ageing\/afz133"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Alwidyan T, McCorry NK, Parsons C. Healthcare professionals' perspectives of deprescribing in older patients at the end of life in hospice care: a qualitative study using the Theoretical Domains Framework. Int J Pharm Pract. 2023;31(3):305-13. https:\/\/doi.org\/10.1093\/ijpp\/riad005","DOI":"10.1093\/ijpp\/riad005"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Massuda A, Hone T, Leles FAG, Castro MC, Atun R. The Brazilian health system at crossroads: progress, crisis and resilience. BMJ Glob Health. 2018;3(4):e000829. https:\/\/doi.org\/10.1136\/bmjgh-2018-000829","DOI":"10.1136\/bmjgh-2018-000829"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Massuda A. Primary health care financing changes in the Brazilian Health System: advance or setback? Cien Saude Colet. 2020;25(4):1181-8. https:\/\/doi.org\/10.1590\/1413-81232020254.01022020","DOI":"10.1590\/1413-81232020254.01022020"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Mendes M, Trindade LL, Pires DEP, Biff D, Martins MMFPS, Vendruscolo C. Cargas de trabalho na Estrat\u00e9gia Sa\u00fade da Fam\u00edlia: interfaces com o desgate dos profissionais de enfermagem. Rev Esc Enferm USP. 2020;54:e03622. https:\/\/doi.org\/10.1590\/S1980-220X2019005003622","DOI":"10.1590\/s1980-220x2019005003622"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Patient autonomy in deprescribing: a qualitative study of the beliefs of older adults and caregivers. Gerontologist. 2015;55(Suppl 2):255-6. https:\/\/doi.org\/10.1093\/geront\/gnv568.13","DOI":"10.1093\/geront\/gnv568.13"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Ouellet N, Bergeron AS, Gagnon E, Cossette B, Labrecque CA, Sirois C. Prescribing and deprescribing in very old age: perceptions of very old adults, caregivers and health professionals. Age Ageing. 2022;51(11):afac244. https:\/\/doi.org\/10.1093\/ageing\/afac244","DOI":"10.1093\/ageing\/afac244"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Arrais PSD, Brito LL, Barreto ML, Coelho HLL. Prevalence and determinants of medication use in the municipality of Fortaleza, Cear\u00e1, Brazil. Cad Saude Publica. 2005;21(6):1737-46. https:\/\/doi.org\/10.1590\/S0102-311X2005000600021","DOI":"10.1590\/S0102-311X2005000600021"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Carvalho SR, Rodrigues CO, Costa FD, Andrade HS. Medicaliza\u00e7\u00e3o: uma crit\u00edca (im)pertinente? Introduc\u00e3o. Physis. 2015;25(4):1251-69. https:\/\/doi.org\/10.1590\/S0103-73312015000400011","DOI":"10.1590\/S0103-73312015000400011"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Schneider LR, Pereira RPG, Ferraz L. Evidence-based practice and sociocultural analysis in primary care. Physis. 2020;30(2):e300232. https:\/\/doi.org\/10.1590\/S0103-73312020300232","DOI":"10.1590\/s0103-73312020300232"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Schimith MD, Simon BS, Br\u00eatas ACP, Bud\u00f3 MLD. Rela\u00e7\u00f5es entre profissionais de sa\u00fade e usu\u00e1rios durante as pr\u00e1ticas em sa\u00fade. Trab Educ Sa\u00fade. 2011;9(3):479-503. https:\/\/doi.org\/10.1590\/S1981-77462011000300008","DOI":"10.1590\/S1981-77462011000300008"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Farrell B, Pottie K, Rojas-Fernandez CH, Bjerre LM, Thompson W, Welch V. Methodology for developing deprescribing guidelines: using evidence and GRADE to guide recommendations for deprescribing. PLoS One. 2016;11(8):e0161248. https:\/\/doi.org\/10.1371\/journal.pone.0161248","DOI":"10.1371\/journal.pone.0161248"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Reeve E, Shakib S, Hendrix I, Roberts MS, Wiese MD. Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process. Br J Clin Pharmacol. 2014;78(4):738-47. https:\/\/doi.org\/10.1111\/bcp.12386","DOI":"10.1111\/bcp.12386"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Scott IA, Hilmer SN, Reeve E, Potter K, Le Couteur D, Rigby D, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med. 2015;175(5):827-34. https:\/\/doi.org\/10.1001\/jamainternmed.2015.0324","DOI":"10.1001\/jamainternmed.2015.0324"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ibrahim K, Cox NJ, Stevenson JM, Lim S, Fraser SDS, Roberts HC. A systematic review of the evidence for deprescribing interventions among older people living with frailty. BMC Geriatr. 2021;21(1):258. https:\/\/doi.org\/10.1186\/s12877-021-02208-8","DOI":"10.1186\/s12877-021-02208-8"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Farrell B, Pottie K, Rojas-Fernandez CH, Bjerre LM, Thompson W, Welch V. Methodology for developing deprescribing guidelines: using evidence and GRADE to guide recommendations for deprescribing. 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