{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:21:32Z","timestamp":1763018492103,"version":"3.37.3"},"reference-count":25,"publisher":"Korean Shoulder and Elbow Society","issue":"1","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["cisejournal.org"],"crossmark-restriction":true},"short-container-title":["Clin Shoulder Elbow"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Background: There are various conservative treatment options for lateral epicondylitis (LE). The aim is to evaluate pain, daily functioning, and complications after ultrasound-standardized autologous blood injections in patients with LE. Methods: For this prospective cohort study, consecutive patients (&gt;18 years) diagnosed with LE were included. Autologous blood was injected using a medical device containing an injection disposable with 12 small needles (Instant Tennis Elbow Cure [ITEC]) device. Patient-Rated Tennis Elbow Evaluation (PRTEE), subjective elbow score (SES), palpation and provocation pain, satisfaction, and complications of treatment were measured at baseline and two months after treatment. Paired t-tests and Fisher\u2019s exact tests were used for calculating the difference between pre- and post-treatment outcomes.Results: Fifty-five elbows were analyzed. Mean time between pre- and post-treatment was 11.1 weeks (standard deviation [SD], 8.9 weeks). The mean PRTEE score decreased from 68.2 (SD, 15.7) before surgery to 53.2 (SD, 25.9; p&lt;0.001) after. The mean SES improved from 36.9 (SD, 20.8) to 51.7 (SD, 27.4; p&lt;0.001). Despite this improvement, only 44.7% of patients showed relevant clinical improvement in PRTEE, and 37.3% showed significant clinical improvement based on SES. Four patients reported a complication and the injection disposable failed three times. Conclusion: Ultrasound-standardized autologous blood injection using the ITEC device is not an effective tool in reducing symptoms related to LE. This study showed that only half of all patients experienced a positive effect. In this heterogeneous cohort of patients, we showed no added value of ultrasound standardization.<\/jats:p>","DOI":"10.5397\/cise.2021.00339","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:45:31Z","timestamp":1642639531000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.5397\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of the efficacy and safety of ultrasound-standardized autologous blood injection as treatment for lateral epicondylitis"],"prefix":"10.5397","volume":"25","author":[{"given":"Christel","family":"Braaksma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Otte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald N.","family":"Wessel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-1417","authenticated-orcid":true,"given":"Nienke","family":"Wolterbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3351","reference":[{"key":"ref1","first-page":"1065","volume-title":"Prevalence and determinants of lateral and medial epicondylitis: a population study","author":"Shiri","year":"2006"},{"key":"ref2","first-page":"642","volume-title":"Prevalence and impact of musculoskeletal disorders of the upper limb in the general population","author":"Walker-Bone","year":"2004"},{"key":"ref3","first-page":"1076","volume-title":"Hand dominance in upper extremity musculoskeletal disorders","author":"Shiri","year":"2007"},{"key":"ref4","first-page":"927","volume-title":"Tennis elbow in primary care","author":"Smidt","year":"2006"},{"key":"ref5","first-page":"2325967116670635","volume-title":"Lateral elbow tendinopathy: development of a pathophysiology-based treatment algorithm","author":"Bhabra","year":"2016"},{"key":"ref6","first-page":"43","volume-title":"Lateral and medial epicondylitis: role of occupational factors","author":"Shiri","year":"2011"},{"key":"ref7","first-page":"CD010951","volume-title":"Autologous blood and platelet-rich plasma injection therapy for lateral elbow pain","author":"Karjalainen","year":"2021"},{"key":"ref8","first-page":"1892","volume-title":"Platelet-rich plasma or autologous blood do not reduce pain or improve function in patients with lateral epicondylitis: a randomized controlled trial","author":"Linnanm\u00e4ki","year":"2020"},{"key":"ref9","first-page":"101","volume-title":"Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis","author":"Arirachakaran","year":"2016"},{"key":"ref10","first-page":"1751","volume-title":"Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials","author":"Coombes","year":"2010"},{"key":"ref11","first-page":"1435","volume-title":"Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials","author":"Krogh","year":"2013"},{"key":"ref12","first-page":"463","volume-title":"Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients","author":"Mishra","year":"2014"},{"key":"ref13","first-page":"573","volume-title":"Ultrasound-guided elbow procedures","author":"Sussman","year":"2016"},{"key":"ref14","first-page":"2130","volume-title":"Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial","author":"Thanasas","year":"2011"},{"key":"ref15","first-page":"1694","volume-title":"The influence of ultrasound guidance in the rate of success of acromioclavicular joint injection: an experimental study on human cadavers","author":"Borbas","year":"2012"},{"key":"ref16","first-page":"1862","volume-title":"A randomized, double-blind, controlled study of ultrasound-guided corticosteroid injection into the joint of patients with inflammatory arthritis","author":"Cunnington","year":"2010"},{"key":"ref17","first-page":"732","volume-title":"Accuracy of ultrasound-guided versus unguided pes anserinus bursa injections","author":"Finnoff","year":"2010"},{"key":"ref18","first-page":"1069","volume-title":"Accuracy of the biceps tendon sheath injection: ultrasound-guided or unguided injection? A randomized controlled trial","author":"Hashiuchi","year":"2011"},{"key":"ref19","first-page":"479","volume-title":"Ultrasound versus palpation guidance for intra-articular injections in patients with degenerative osteoarthritis of the elbow","author":"Kim","year":"2013"},{"key":"ref20","first-page":"564","volume-title":"The accuracy of ultrasound-guided and palpation-guided peroneal tendon sheath injections","author":"Muir","year":"2011"},{"key":"ref21","first-page":"377","volume-title":"Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support","author":"Harris","year":"2009"},{"key":"ref22","first-page":"270","volume-title":"Cross-cultural adaptation and reliability and validity of the Dutch Patient-Rated Tennis Elbow Evaluation (PRTEE-D)","author":"van Ark","year":"2014"},{"key":"ref23","first-page":"308","volume-title":"Comparison of the subjective elbow value and the Mayo elbow performance score","author":"Schneeberger","year":"2014"},{"key":"ref24","first-page":"419","volume-title":"Non-surgical treatment of lateral epicondylitis: a systematic review of randomized controlled trials","author":"Sims","year":"2014"},{"key":"ref25","first-page":"2053","volume-title":"Lateral epicondylitis in general practice: course and prognostic indicators of outcome","author":"Smidt","year":"2006"}],"container-title":["Clinics in Shoulder and Elbow"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cisejournal.org\/upload\/pdf\/cise-2021-00339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cisejournal.org\/journal\/view.php?doi=10.5397\/cise.2021.00339","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cisejournal.org\/upload\/pdf\/cise-2021-00339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T04:01:19Z","timestamp":1646020879000},"score":1,"resource":{"primary":{"URL":"http:\/\/cisejournal.org\/journal\/view.php?doi=10.5397\/cise.2021.00339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"URL":"https:\/\/doi.org\/10.5397\/cise.2021.00339","relation":{},"ISSN":["2288-8721"],"issn-type":[{"type":"electronic","value":"2288-8721"}],"subject":[],"published":{"date-parts":[[2022,3,1]]},"assertion":[{"value":"2021-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-20","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}