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A thorough consideration of medical history and physical examination is essential to rule out other causes of symptomatic TSA\u2014namely, periprosthetic joint infection\u2014as symptoms often progress to vague pain or discomfort due to subtle component loosening. Once confirmed, nonoperative treatment of osteolysis should first be pursued given the potential to avoid surgery-associated risks. If needed, the current surgical options include glenoid polyethylene revision and conversion to reverse shoulder arthroplasty. The current article provides a comprehensive review of the evaluation and management of osteolysis after TSA through an evidence-based discussion of current concepts.<\/jats:p>","DOI":"10.5397\/cise.2021.00738","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T06:02:20Z","timestamp":1658124140000},"page":"244-254","update-policy":"https:\/\/doi.org\/10.5397\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pathogenesis, Evaluation, and Management of Osteolysis After Total Shoulder Arthroplasty"],"prefix":"10.5397","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-3482","authenticated-orcid":true,"given":"Kyle N.","family":"Kunze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Krivicich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Brusalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence V.","family":"Gulotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Dines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3351","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2020.03.049"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600759720"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s1058-2746(97)90081-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s1058-2746(96)80030-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.f.00125"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001711011133"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2007.12.004"},{"key":"ref8","first-page":"483","volume-title":"The pathology of total joint arthroplasty.II. 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