{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:28:10Z","timestamp":1772202490357,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T00:00:00Z","timestamp":1301961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pediatrics"],"published-print":{"date-parts":[[2011,4,5]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Functional dyspepsia is a common chronic disorder with non specific upper abdominal pain or discomfort. Different approaches with anti-secretory, spasmolytic, prokinetic and anti-inflammatory effects and most preferably reduction of visceral hypersensitivity seem logical. In this study, we compared the effectiveness of the four most drugs used for treatment of dyspepsia in children. <jats:italic>Methods<\/jats:italic>. 169 patients between 2 to 16 years old that 47.3% was male and 52.7% was female were enrolled in this clinical trial study by the diagnosis of functional dyspepsia. Then for each patient one of the drugs; Omeprazole, Famotidine, Ranitidine or Cimetidine was administered, for a period of 4 weeks. Patients were followed after 2 and 6 weeks from the beginning of the treatment. <jats:italic>Results<\/jats:italic>. The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine (). In followups within 2 and 6 weeks after beginning medical therapy, no side effects due to drugs were seen. <jats:italic>Conclusion<\/jats:italic>. If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia.<\/jats:p>","DOI":"10.5402\/2011\/219287","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T19:32:49Z","timestamp":1302031969000},"page":"1-5","source":"Crossref","is-referenced-by-count":26,"title":["The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia"],"prefix":"10.5402","volume":"2011","author":[{"given":"Seyed Mohsen","family":"Dehghani","sequence":"first","affiliation":[{"name":"Gastroenterohepatology Research Center, Pediatric Gastroenterology Department, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz 71937-11351, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad 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