{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:36:39Z","timestamp":1788870999457,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:00:00Z","timestamp":1302739200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012359","name":"Promotion and Mutual Aid Corporation for Private Schools of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pharmacology"],"published-print":{"date-parts":[[2011,4,14]]},"abstract":"<jats:p>\n                    Anthracyclines, most powerful anticancer agents, suffer from their cardiotoxic effects, which may be due to the induction of oxidative stress. Carvedilol, a third-generation, nonselective\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mi>\u03b2<\/mml:mi>\n                    <\/mml:math>\n                    -adrenoreceptor antagonist, possesses both reactive oxygen species (ROS) scavenging and ROS suppressive effects. It showed protective effects against daunorubicin- (DNR-) induced cardiac toxicity by reducing oxidative stress and apoptosis. This study therefore was designed to examine the effects of carvedilol on DNR-induced cardiomyopathic rats, focused on the changes of left ventricular function, cardiac fibrosis, and hypertrophy. Carvedilol increased survival rate, prevented systolic and diastolic dysfunction, and attenuated myocardial fibrosis and hypertrophy. DNR alone treated rats showed upregulated myocardial expression of ANP, PKC-\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mi>\u03b1<\/mml:mi>\n                    <\/mml:math>\n                    , OPN, and TGF-\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>\u03b2<\/mml:mi>\n                        <mml:mn>1<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    and downregulation of GATA-4 in comparison with control, and treatment with carvedilol significantly reversed these changes. The results of the present study add the available evidences on the cardioprotection by carvedilol when associated with anthracyclines and explain the mechanisms underlying the benefits of their coadministration.\n                  <\/jats:p>","DOI":"10.5402\/2011\/430549","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T15:33:22Z","timestamp":1302795202000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats\n                    <i>In Vivo<\/i>\n                    : Effects on Cardiac Fibrosis and Hypertrophy"],"prefix":"10.5402","volume":"2011","author":[{"given":"Wawaimuli","family":"Arozal","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"},{"name":"Department of Pharmacology, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flori R.","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"},{"name":"Department of Pharmacology, Faculty of Medicine and Health Sciences, Syarif Hidayatullah Jakarta, State Islamic University, South Jakarta 15412, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somasundaram","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punniyakoti T.","family":"Veeraveedu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarajan A.","family":"Thandavarayan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayakumar","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Prasath","family":"Lakshmanan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyasu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Mito","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Soetikno","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima Akiha-Ku, Niigata City 956-8603, Japan"},{"name":"Department of Pharmacology, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.05.005"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0002-9149(81)90534-8","volume":"47","year":"1981","journal-title":"American Journal of Cardiology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(90)90088-J"},{"issue":"6","key":"4","first-page":"865","volume":"62","year":"1978","journal-title":"Cancer Treatment Reports"},{"issue":"7","key":"5","first-page":"1","volume":"55","year":"1984","journal-title":"Archives of Toxicology Supplement"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-005-0138-0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.122820"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2006.10.002"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605233342101"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.CIR.100.4.346","volume":"100","year":"1999","journal-title":"Circulation"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00326-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00671-9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.05.003"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.010"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.052"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.08.061"},{"issue":"7","key":"17","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/sj.bjp.0703450","volume":"130","year":"2000","journal-title":"British Journal of Pharmacology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.06.023"},{"issue":"1","key":"19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","year":"1985","journal-title":"Analytical Biochemistry"},{"issue":"5","key":"20","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1172\/JCI114044","volume":"83","year":"1989","journal-title":"Journal of Clinical Investigation"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(01)00139-5"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22495"},{"issue":"4299","key":"23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1126\/science.877547","volume":"197","year":"1977","journal-title":"Science"},{"issue":"1","key":"24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/scdb.1998.0281","volume":"10","year":"1999","journal-title":"Seminars in Cell and Developmental Biology"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R000029200"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102174200"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.2.368"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.05.024"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605192"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01285.2008"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128621.68160.dd"},{"issue":"9","key":"32","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/01.CIR.96.9.3063","volume":"96","year":"1997","journal-title":"Circulation"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.8.917"},{"issue":"4","key":"34","first-page":"531","volume":"43","year":"2002","journal-title":"Journal of Nuclear Medicine"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.47.607"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02336.x"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.08.065"}],"container-title":["ISRN Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/430549.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/430549.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/430549.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T17:34:29Z","timestamp":1607448869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2011\/430549\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,14]]},"references-count":37,"alternative-id":["430549","430549"],"URL":"https:\/\/doi.org\/10.5402\/2011\/430549","relation":{},"ISSN":["2090-5165","2090-5173"],"issn-type":[{"value":"2090-5165","type":"print"},{"value":"2090-5173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,14]]}}}