{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:23:44Z","timestamp":1740162224448,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,12,25]],"date-time":"2011-12-25T00:00:00Z","timestamp":1324771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["H75\/CCH224064"],"award-info":[{"award-number":["H75\/CCH224064"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Endocrinology"],"published-print":{"date-parts":[[2011,12,25]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Assess the prevalence of abnormal glucose metabolism among Hispanic parents of children with acanthosis nigricans (AN). <jats:italic>Methods<\/jats:italic>. Hispanic families <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>258<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math> were evaluated for metabolic and anthropometric parameters including fasting glucose levels and AN status. <jats:italic>Results<\/jats:italic>. Mothers with AN+ children had IFG (17.3%) and 4% had glucose levels \u2265126\u2009mg\/dL <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.028<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math> compared to 7.1% and 1.8% of mothers with AN\u2212 children, respectively. Mothers of AN+ children also had greater odds of having impaired fasting glucose levels (OR: 3.917, 95% CI: 1.475\u201310.404; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:mrow><\/mml:math>) but this was not the case for fathers (OR: 1.125, 95% CI: 0.489\u20132.586; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.781<\/mml:mn><\/mml:mrow><\/mml:math>). Mothers of AN+ children were also more likely to be AN+ (OR: 5.76, 95% CI: 2.98\u201311.13, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). Screening discovered glucose levels &gt;126\u2009mg\/dL in 9% of fathers with AN+ children. <jats:italic>Conclusions<\/jats:italic>. Hispanic mothers of AN+ children are at higher risk of carbohydrate metabolism abnormalities. AN in children can be a marker for prevention and delay programs aimed at identifying adults at risk for diabetes.<\/jats:p>","DOI":"10.5402\/2011\/481371","type":"journal-article","created":{"date-parts":[[2011,12,25]],"date-time":"2011-12-25T21:30:27Z","timestamp":1324848627000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Abnormal Glucose Metabolism in Hispanic Parents of Children with Acanthosis Nigricans"],"prefix":"10.5402","volume":"2011","author":[{"given":"Ximena","family":"Urrutia-Rojas","sequence":"first","affiliation":[{"name":"Department of Management, Policy, and Community Health, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"McConathy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort 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