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GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.<\/jats:p>","DOI":"10.5402\/2011\/497850","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T21:30:12Z","timestamp":1311629412000},"page":"1-8","source":"Crossref","is-referenced-by-count":28,"title":["Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features"],"prefix":"10.5402","volume":"2011","author":[{"given":"J\u00f4ice Dias","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Martins","family":"Queiroz-Junior","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal 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