{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:03:53Z","timestamp":1788264233533,"version":"build-2803163510"},"reference-count":93,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Hematology"],"published-print":{"date-parts":[[2011,6,16]]},"abstract":"<jats:p>Anthracycline-based chemotherapy remains standard treatment for peripheral T-cell lymphoma (PTCL) although its benefits have been questioned. We performed systematic literature review and meta-analyses examining the complete response (CR) and overall survival (OS) rates for patients with PTCL. The CR rate for PTCL patients ranged from 35.9% (95% CI 23.4\u201350.7%) for enteropathy-type T-cell lymphoma (ETTL) to 65.8% (95% CI 54.0\u201375.9%) for anaplastic large cell lymphoma (ALCL). The 5-year OS was 38.5% (95% CI 35.5\u201341.6%) for all PTCL patients and ranged from 20.3% (95% CI 12.5\u201331.2%) for ETTL to 56.5% (95% CI 42.8\u201369.2%) for ALCL. These data suggest that there is marked heterogeneity across PTCL subtypes in the benefits of anthracycline-based chemotherapy. While anthracyclines produce CR in half of PTCL patients, this yields reasonable 5-year OS for patients with ALCL but not for those with PTCL-NOS or ETTL. Novel agents and regimens are needed to improve outcomes for these patients.<\/jats:p>","DOI":"10.5402\/2011\/623924","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T07:07:05Z","timestamp":1308640025000},"page":"1-14","source":"Crossref","is-referenced-by-count":115,"title":["A Systematic Review and Meta-Analysis of  Front-line Anthracycline-Based Chemotherapy  Regimens for Peripheral T-Cell Lymphoma"],"prefix":"10.5402","volume":"2011","author":[{"given":"Abeer N.","family":"AbouYabis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mercer University, Central Georgia Cancer Care, 1062 Forsyth Street,  Suite 1B Macon, Georgia, GA 31201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pareen J.","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Winship Cancer Institute, Emory University, 2365 Clifton Road,  N.E. 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