{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:12:45Z","timestamp":1777389165884,"version":"3.51.4"},"reference-count":5,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Health of Sichuan Province","award":["080095"],"award-info":[{"award-number":["080095"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pharmaceutics"],"published-print":{"date-parts":[[2011,6,22]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the mechanism of capsaicin in treating active psoriasis vulgaris.<jats:italic>Methods<\/jats:italic>. HIF-1\u03b1 gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by<jats:italic>in situ<\/jats:italic>hybridization.<jats:italic>Results<\/jats:italic>. There was positive staining of HIF-1\u03b1 gene in all the layers of psoriatic epidermis (100.0%) before the treatment with capsaicin ointment, but the dyeing in epidermis were reduced obviously (22.2%) after the treatment for 21 days.<jats:italic>Conclusion<\/jats:italic>. HIF-1\u03b1 gene translation in psoriatic epidermis was downregulated after capsaicin treatment for 21 days.<\/jats:p>","DOI":"10.5402\/2011\/821874","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T20:00:36Z","timestamp":1308772836000},"page":"1-3","source":"Crossref","is-referenced-by-count":5,"title":["Study on HIF-1\u03b1 Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment"],"prefix":"10.5402","volume":"2011","author":[{"given":"Chun-shui","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046250"},{"issue":"3","key":"2","first-page":"446","volume":"2","year":"2010","journal-title":"Journal of Dermatological Science"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2340\/00015555715154","volume":"71","year":"1991","journal-title":"Acta Dermato-Venereologica"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700880"},{"issue":"9","key":"5","first-page":"952","volume":"35","year":"2010","journal-title":"Journal of Central South University"}],"container-title":["ISRN Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/821874.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/821874.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/821874.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T22:16:52Z","timestamp":1712528212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2011\/821874\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,22]]},"references-count":5,"alternative-id":["821874","821874"],"URL":"https:\/\/doi.org\/10.5402\/2011\/821874","relation":{},"ISSN":["2090-6145","2090-6153"],"issn-type":[{"value":"2090-6145","type":"print"},{"value":"2090-6153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,22]]}}}