{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:31:52Z","timestamp":1762101112441,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T00:00:00Z","timestamp":1323907200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100012386","name":"Magee-Womens Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Obstetrics and Gynecology"],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:p>As the role of distal fallopian tube as organ of serous carcinogenesis is emerging, additional literature on the role of tubal intraepithelial carcinoma (TIC) as a precursor lesion in a subset of primary peritoneal serous carcinomas (PPSC is emerging as well. TIC although fallopian tube in origin can be genetically related to ovarian\/peritoneal carcinomas. The role of PAX2 in primary fallopian tube carcinomas (PFTC)\/PPSC is yet to be defined. The aim of our study was to understand if the biologic properties of tumors arising in the distal fallopian tube that remain as PFTC are different when they seed on to the peritoneal surface (PPSC). A panel of 6 polymorphic microsatellite markers corresponding to p53, PAX2, and WT1 tumor suppressor genes were studied. Invasive carcinomas as well as TIC arising in the distal fallopian tube when remain as PFTC appears to exhibit different LOH patterns in comparison to PPSC. PAX 2 LOH patterns might represent a \u201chidden PAX 2 signature\u201d analogous to p53 signatures. PAX 2 might be an emerging marker for detection of early serous carcinomas particularly in BRCA + women.<\/jats:p>","DOI":"10.5402\/2011\/858647","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T19:50:33Z","timestamp":1292442633000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma: Do They Share a Common \u201cPrecursor\u201d Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers"],"prefix":"10.5402","volume":"2011","author":[{"given":"Mamatha","family":"Chivukula","sequence":"first","affiliation":[{"name":"Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo A.","family":"Niemeier","sequence":"additional","affiliation":[{"name":"Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Nikiforova","sequence":"additional","affiliation":[{"name":"Molecular Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Mantha","sequence":"additional","affiliation":[{"name":"Molecular Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"McManus","sequence":"additional","affiliation":[{"name":"Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Carter","sequence":"additional","affiliation":[{"name":"Molecular Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213335.40358.47"},{"year":"2003","key":"20"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.01.013"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000092130.10100.88"},{"issue":"2","key":"14","first-page":"122","volume":"12","year":"2004","journal-title":"Applied Immunohistochemistry and Molecular Morphology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2007.702"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4814"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.01.012"},{"issue":"9","key":"6","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/bies.950190905","volume":"19","year":"1997","journal-title":"BioEssays"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.22753"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.07.018"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800535"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181a76fa2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800827"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01787.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200404000-00005"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e31814b191f"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/path.2739"}],"container-title":["ISRN Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/858647.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/858647.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/858647.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:48:31Z","timestamp":1607474911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2011\/858647\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,15]]},"references-count":18,"alternative-id":["858647","858647"],"URL":"https:\/\/doi.org\/10.5402\/2011\/858647","relation":{},"ISSN":["2090-4436","2090-4444"],"issn-type":[{"type":"print","value":"2090-4436"},{"type":"electronic","value":"2090-4444"}],"subject":[],"published":{"date-parts":[[2011,12,15]]}}}