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With the increasing prevalence of impaired glucose tolerance (IGT) seen in obese individuals, the present study was aimed to investigate the basal immune response and immune response upon Hepatitis B vaccination (HBV) in an obese rat model WNIN\/GR-Ob with impaired glucose tolerance (IGT). Decreased proportions of splenic CD4<jats:sup>+<\/jats:sup>T helper cells and CD3<jats:sup>+<\/jats:sup>T cells were observed in obese animals compared to lean animals. Upon HBV, obese animals showed reduced cell-mediated immunity and humoral immunity in terms of splenic lymphocyte proliferative response to Concanavalin A (Con A) and Hepatitis B surface antigen (HBsAg) and HBsAg-specific IgG response. Innate immunity as assessed in terms of Tumor Necrosis Factor<jats:italic>\u03b1<\/jats:italic>(TNF<jats:italic>\u03b1<\/jats:italic>) and Nitric oxide (NO) production by peritoneal macrophages upon HBV was low and unchanged, respectively, in obese animals. 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