{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:19:37Z","timestamp":1790648377161,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["55751\/2005"],"award-info":[{"award-number":["55751\/2005"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["55751\/2005"],"award-info":[{"award-number":["55751\/2005"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Endocrinology"],"published-print":{"date-parts":[[2012,12,17]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Chronic autoimmune thyroiditis (CAT) frequently alters thyroid vascularization, likely as a result of the autoimmune process. <jats:italic>Objective<\/jats:italic>. To evaluate the effects of low-level laser therapy (LLLT) on the thyroid vascularization of patients with hypothyroidism induced by CAT using color Doppler ultrasound parameters. <jats:italic>Methods<\/jats:italic>. In this randomized clinical trial, 43 patients who underwent levothyroxine replacement for CAT-induced hypothyroidism were randomly assigned to receive either 10 sessions of LLLT (L group, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>23<\/mml:mn><\/mml:mrow><\/mml:math>) or 10 sessions of a placebo treatment (P group, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:math>). Color Doppler ultrasounds were performed before and 30 days after interventions. To verify the vascularity of the thyroid parenchyma, power Doppler was performed. The systolic peak velocity (SPV) and resistance index (RI) in the superior (STA) and inferior thyroid arteries (ITAs) were measured by pulsed Doppler. <jats:italic>Results<\/jats:italic>. The frequency of normal vascularization of the thyroid lobes observed in the postintervention power Doppler examination was significantly higher in the L than in the P group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.023<\/mml:mn><\/mml:math>). The pulsed Doppler examination revealed an increase in the SPV of the ITA in the L group compared with the P group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.016<\/mml:mn><\/mml:math>). No significant differences in the SPV of the STA and in the RI were found between the groups. <jats:italic>Conclusion<\/jats:italic>. These results suggest that LLLT can ameliorate thyroid parenchyma vascularization and increase the SPV of the ITA of patients with hypothyroidism caused by CAT.<\/jats:p>","DOI":"10.5402\/2012\/126720","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T21:20:05Z","timestamp":1355779205000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of the Effects of Low-Level Laser Therapy on the Thyroid Vascularization of Patients with Autoimmune Hypothyroidism by Color Doppler Ultrasound"],"prefix":"10.5402","volume":"2012","author":[{"given":"Danilo Bianchini","family":"H\u00f6fling","sequence":"first","affiliation":[{"name":"Ultrasound Unit, Department of Radiology, Clinics Hospital, University of Sao Paulo Medical School, 05403-000 S\u00e3o Paulo, SP, Brazil"},{"name":"Laser Medical Center, Heart Institute, Clinics Hospital, University of Sao Paulo Medical School,  05403-000 S\u00e3o Paulo, SP, 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