{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:53:11Z","timestamp":1761155591519},"reference-count":39,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Orthopedics"],"published-print":{"date-parts":[[2012,5,29]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To compare the effects of intra-articular application of statin and tetracyclines on cartilage and synovial tissue on experimental osteoarthritis.\n    <jats:italic>Methods<\/jats:italic>. Osteoarthritis was created in 30 rabbits of 3 groups. The control group received saline intra-articularly,  statin group, atorvastatin and the tetracycline group, doxycycline once a week for 3 weeks. Chondral and synovial tissues were evaluated macroscopically and histopathologically.\n    <jats:italic>Results<\/jats:italic>. Macroscopic evaluation determined mean values of control group 3.0, statin group 0.56, and tetracycline group 2.5. Histopathological evaluations determined mean values;  femoral medial condyle cartilage tissue, control group, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>14.60<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.00<\/mml:mn><\/mml:mrow><\/mml:math>, statin group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>2.20<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.30<\/mml:mn><\/mml:mrow><\/mml:math>, tetracycline group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>12.7<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>5.39<\/mml:mn><\/mml:mrow><\/mml:math>: tibia medial plateau, control group, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>14.33<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>8.68<\/mml:mn><\/mml:mrow><\/mml:math>, statin group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>2.89<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.96<\/mml:mn><\/mml:mrow><\/mml:math>, tetracycline group, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>15.90<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>7.03<\/mml:mn><\/mml:mrow><\/mml:math>: synovial tissue, control group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>12.22<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.63<\/mml:mn><\/mml:mrow><\/mml:math>, statin group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>4.33<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.69<\/mml:mn><\/mml:mrow><\/mml:math>, tetracycline group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>10.70<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.62<\/mml:mn><\/mml:mrow><\/mml:math>. Average values of synovial tissue cell layer thickness were control group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>14.46<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.35<\/mml:mn><\/mml:mrow><\/mml:math>\u2009\u03bcm, statin group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>10.56<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.01<\/mml:mn><\/mml:mrow><\/mml:math>\u2009\u03bcm, tetracycline group <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>12.80<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.79<\/mml:mn><\/mml:mrow><\/mml:math>\u2009\u03bcm. All measurements showed  statistically significant differences between statin and control groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) but not between tetracycline and control groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>).\n    <jats:italic>Conclusions<\/jats:italic>. Tetracycline has little effect due to chemical modification requirement, and the effect is dose dependent. Statins have chondroprotective effects, so may become a novel therapeutic agent in osteoarthritis management after chemical processing.<\/jats:p>","DOI":"10.5402\/2012\/182097","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T08:17:28Z","timestamp":1339575448000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["An Assessment of the Chondroprotective Effects of Intra-Articular Application of Statin and Tetracycline on Early-Stage Experimental Osteoarthritis"],"prefix":"10.5402","volume":"2012","author":[{"given":"Mustafa","family":"Dinc","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Nizip State Hospital, Gaziantep, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Sadik","family":"Bilgen","sequence":"additional","affiliation":[{"name":"Ortopedi ve Travmatoloji B\u00f6l\u00fcm\u00fc, T\u0131p Fak\u00fcltesi, Uluda\u011f \u00dcniversitesi, 16059, 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