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OVX rats of Wistar strain were used in all experiments. Two weeks after surgery rats were chronically treated with vehicle, a low dose of 17<jats:italic>\u03b2<\/jats:italic>-E<jats:sub>2<\/jats:sub>(5.0\u2009<jats:italic>\u03bc<\/jats:italic>g\/rat), quinpirole (0.1\u2009mg\/kg), sulpiride (10.0\u2009mg\/kg), quinpirole plus 17<jats:italic>\u03b2<\/jats:italic>-E<jats:sub>2<\/jats:sub>, or sulpiride plus 17<jats:italic>\u03b2<\/jats:italic>-E<jats:sub>2<\/jats:sub>for 14 days before the forced swimming test. We found that sulpiride significantly decreased immobility time in the OVX females. A combination of sulpiride with a low dose of 17<jats:italic>\u03b2<\/jats:italic>-E<jats:sub>2<\/jats:sub>induced more profound decrease of immobility time in the OVX rats compared to the rats treated with sulpiride alone. On the contrary, quinpirole failed to modify depression-like behavior in the OVX rats. In addition, quinpirole significantly blocked the antidepressant-like effect of 17<jats:italic>\u03b2<\/jats:italic>-E<jats:sub>2<\/jats:sub>in OVX rats. Thus, the D<jats:sub>2<\/jats:sub>receptor antagonist sulpiride alone or in combination with a low dose of 17<jats:italic>\u03b2<\/jats:italic>-E<jats:sub>2<\/jats:sub>exerted antidepressant-like effect in OVX female rats, while the D<jats:sub>2<\/jats:sub>receptor agonist quinpirole produced depressant-like profile on OVX rats.<\/jats:p>","DOI":"10.5402\/2012\/305645","type":"journal-article","created":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T17:01:33Z","timestamp":1330707693000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Stimulation and Blockade of Receptor on Depression-Like Behavior in Ovariectomized Female Rats"],"prefix":"10.5402","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-9299","authenticated-orcid":true,"given":"Julia","family":"Fedotova","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology of the Russian Academy of Science, 6 Emb. 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