{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T08:29:52Z","timestamp":1724142592673},"reference-count":36,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pediatrics"],"published-print":{"date-parts":[[2012,9,3]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Recurrent perianal inflammation has great etiologic diversity. A possible cause is cow\u2019s milk allergy (CMA). The aim was to assess the magnitude of this cause.<jats:italic>Subjects and Methods<\/jats:italic>. This follow up clinical study was carried out on 63 infants with perianal dermatitis of more than 3 weeks with history of recurrence. Definitive diagnosis was made for each infant through medical history taking, clinical examination and investigations including stool analysis and culture, stool pH and reducing substances, perianal swab for different cultures and staining for<jats:italic>Candida albicans<\/jats:italic>. Complete blood count and quantitative determination of cow\u2019s milk-specific serum IgE concentration were done for all patients. CMA was confirmed through an open withdrawal-rechallenge procedure. Serum immunoglobulins and CD markers as well as gastrointestinal endoscopies were done for some patients.<jats:italic>Results<\/jats:italic>. Causes of perianal dermatitis included CMA (47.6%), bacterial dermatitis (17.46%), moniliasis (15.87%), enterobiasis (9.52%) and lactose intolerance (9.5%). Predictors of CMA included presence of bloody and\/or mucoid stool, other atopic manifestations, anal fissures, or recurrent vomiting.<jats:italic>Conclusion<\/jats:italic>. We can conclude that cow\u2019s milk allergy is a common cause of recurrent perianal dermatitis. Mucoid or bloody stool, anal fissures or ulcers, vomiting and atopic manifestations can predict this etiology.<\/jats:p>","DOI":"10.5402\/2012\/408769","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T21:30:29Z","timestamp":1346707829000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Cow\u2019s Milk Allergy Is a Major Contributor in Recurrent Perianal Dermatitis of Infants"],"prefix":"10.5402","volume":"2012","author":[{"given":"Mostafa Abdel-Aziz","family":"El-Hodhod","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Abbassia, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Mohamed","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Abbassia, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa 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