{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:56:17Z","timestamp":1774954577249,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,11,4]],"date-time":"2012-11-04T00:00:00Z","timestamp":1351987200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012,11,4]]},"abstract":"<jats:p>Gastro-oesophageal reflux (GER) and the symptoms of heartburn and regurgitation are common in pregnancy. These symptoms are transient and mostly resolve postpartum but have a negative impact on quality of life. Here, we present a prospective clinical evaluation of the safety and efficacy of an alginate raft-forming oral suspension that is licensed for use in pregnancy. The study was a multicentre, prospective, open-label, and baseline-controlled study of Liquid Gaviscon (LG) in the treatment of heartburn in pregnant women with current symptoms of heartburn and\/or reflux requiring treatment (recruited 144). The efficacy of the study medication was rated by the investigator (primary endpoint) and patient. Treatment was deemed to be a success in 91% of patients as judged by the investigator (95% CI 85.0\u201395.3) and 90% (95% CI 84.1\u201394.8) when assessed by the patient themselves. Very few adverse events or serious adverse events were reported that were considered to be related to the study medication, and these were consistent with the normal population incidences. Serum sodium levels remained unchanged. This prospective open-label study in a large number of pregnant women has shown that LG is both safe and highly efficacious in the treatment of heartburn and GER symptoms in pregnancy.<\/jats:p>","DOI":"10.5402\/2012\/481870","type":"journal-article","created":{"date-parts":[[2012,11,4]],"date-time":"2012-11-04T21:00:52Z","timestamp":1352062852000},"page":"1-6","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of the Safety and Efficacy of a Raft-Forming Alginate Reflux Suppressant (Liquid Gaviscon) for the Treatment of Heartburn during Pregnancy"],"prefix":"10.5402","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-9742","authenticated-orcid":true,"given":"Vicki","family":"Strugala","sequence":"first","affiliation":[{"name":"Technostics Limited, Daisy Building (2nd Floor), Castle Hill Hospital, Castle Road, Kingston Upon Hull HU16 5JQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Bassin","sequence":"additional","affiliation":[{"name":"Medical Centre, Netcare Linksfield Hospital, Suite 205, 12th Avenue, Linksfield West, Johannesburg 2037, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie S.","family":"Swales","sequence":"additional","affiliation":[{"name":"Elm Lane Surgery, Sheffield S5 7TW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-1971","authenticated-orcid":true,"given":"Stephen W.","family":"Lindow","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Hull Royal Infirmary, Anlaby Road, Kingston Upon Hull HU3 2JZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2931-5025","authenticated-orcid":true,"given":"Peter W.","family":"Dettmar","sequence":"additional","affiliation":[{"name":"Technostics Limited, Daisy Building (2nd Floor), Castle Hill Hospital, Castle Road, Kingston Upon Hull HU16 5JQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-8606","authenticated-orcid":true,"given":"Edward C. M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Global Professional Relations, Reckitt Benckiser Group plc, 103-105 Bath Road, Slough SL1 3UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0932-z"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000209381"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01452.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02654.x"},{"issue":"9","key":"5","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cgh.2007.05.003","volume":"5","year":"2007","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1742-1241.2003.tb10458.x","volume":"57","year":"2003","journal-title":"International Journal of Clinical Practice"},{"key":"7","first-page":"598","volume":"108","year":"1990","journal-title":"Fortschritte der Medizin"},{"issue":"1","key":"8","first-page":"17","volume":"21","year":"1999","journal-title":"Giornale Italiano di Ostetricia e Ginecologia"},{"issue":"7-9","key":"9","first-page":"569","volume":"83","year":"1988","journal-title":"Revue Francaise de Gynecologie et d'Obstetrique"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/0002-9378(88)90090-7","volume":"158","year":"1988","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"6966","key":"16","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1136\/bmj.309.6966.1395","volume":"309","year":"1994","journal-title":"British Medical Journal"},{"issue":"3","key":"17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0306-3356(21)00529-X","volume":"9","year":"1982","journal-title":"Clinics in Obstetrics and Gynaecology"},{"issue":"6","key":"18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443619963815","volume":"19","year":"1999","journal-title":"Journal of Obstetrics and Gynaecology"},{"key":"19","volume-title":"Bleeding in late pregnancy","year":"1994"},{"issue":"10","key":"20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1471-0528.1990.tb02442.x","volume":"97","year":"1990","journal-title":"British Journal of Obstetrics and Gynaecology"},{"issue":"7346","key":"21","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1136\/bmj.324.7346.1118","volume":"324","year":"2002","journal-title":"British Medical Journal"},{"issue":"7","key":"22","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/0002-9378(77)90714-1","volume":"128","year":"1977","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"11","key":"23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1471-0528.1978.tb15833.x","volume":"85","year":"1978","journal-title":"British Journal of Obstetrics and Gynaecology"},{"issue":"6042","key":"24","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1136\/bmj.2.6042.965","volume":"2","year":"1976","journal-title":"British Medical Journal"},{"key":"25","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/0002-9378(90)90653-O","volume":"163","year":"1990","journal-title":"American Journal of Obstetrics & Gynecology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.5.966"},{"issue":"6","key":"11","first-page":"445","volume":"93","year":"2003","journal-title":"South African Medical Journal"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.01.036"},{"issue":"3","key":"13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1185\/03007999909114086","volume":"15","year":"1999","journal-title":"Current Medical Research and Opinion"}],"container-title":["ISRN Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/481870.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/481870.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/481870.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T14:39:56Z","timestamp":1687790396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2012\/481870\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,4]]},"references-count":24,"alternative-id":["481870","481870"],"URL":"https:\/\/doi.org\/10.5402\/2012\/481870","relation":{},"ISSN":["2090-4444"],"issn-type":[{"value":"2090-4444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,4]]}}}