{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:07:29Z","timestamp":1791803249243,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,8,5]],"date-time":"2012-08-05T00:00:00Z","timestamp":1344124800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pediatrics"],"published-print":{"date-parts":[[2012,8,5]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Ongoing surveillance of antimicrobial sensitivity patterns of bacteria isolated in bloodstream infections guides empiric antibiotic therapy in neonatal sepsis.<jats:italic>Methods<\/jats:italic>. Sensitivity profiles of neonatal bacterial bloodstream infections in a tertiary hospital were reviewed between 01\/06\/2009 and 30\/06\/2010 .<jats:italic>Results<\/jats:italic>. There were 246 episodes of bloodstream infection in 181 individuals\u2014(14.06 episodes in10.35 patients\/1000 patient days or 14.4 episodes in 10.6 babies\/1000 live births. The majority were (93.5%) were late onset and most (54.9%) were gram positive. There were 2.28 sepsis-related deaths \/1000 patient days or 2.3\/1000 live births. Death was significantly associated with gram-negative infections (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), multiple gestation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), shock (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>), NEC (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>), and shorter duration of hospital stay (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). Coagulase-negative staphylococcus was isolated in 19.1%,<jats:italic>K. pneumoniae<\/jats:italic>ESBL in 12.1%, and<jats:italic>A. baumanni<\/jats:italic>in 10.9%.<jats:italic>S. agalactiae<\/jats:italic>predominated in early onset sepsis. Methicillin resistance was present in 86% of CoNS and 69.5% of<jats:italic>S. aureus<\/jats:italic>; 46% enterococcal isolates were ampicillin resistant. The majority (65%) of<jats:italic>K. pneumoniae<\/jats:italic>isolates were ESBL producers. Ampicillin resistance was present in 96% of<jats:italic>E. coli<\/jats:italic>.<jats:italic>Conclusions<\/jats:italic>. Penicillin and an aminoglycoside would be suitable empiric therapy for early onset sepsis and meropenem with gentamycin or ceftazidime with amikacin for late onset sepsis.<\/jats:p>","DOI":"10.5402\/2012\/508512","type":"journal-article","created":{"date-parts":[[2012,8,5]],"date-time":"2012-08-05T21:30:13Z","timestamp":1344202213000},"page":"1-6","source":"Crossref","is-referenced-by-count":67,"title":["Bacterial Bloodstream Infections in Neonates in a Developing Country"],"prefix":"10.5402","volume":"2012","author":[{"given":"Daynia E.","family":"Ballot","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, University of the Witwatersrand, PO Wits, Johannesburg 2050, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trusha","family":"Nana","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, National Health Laboratory Services, P.O. Box 1038, Johannesburg 2000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Sriruttan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, National Health Laboratory Services, P.O. Box 1038, Johannesburg 2000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of the Witwatersrand, PO Wits, Johannesburg 2050, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.06.004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.03.014"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2006.06.013"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31818cb0aa"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7883\/yoken.JJID.2009.46","volume":"62","year":"2009","journal-title":"Japanese Journal of Infectious Diseases"},{"issue":"1","key":"6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","volume":"187","year":"1978","journal-title":"Annals of Surgery"},{"issue":"4","key":"7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","year":"1978","journal-title":"Journal of Pediatrics"},{"issue":"3","key":"8","first-page":"4","volume":"20","year":"2005","journal-title":"Southern African Journal of Epidemiology and Infection"},{"issue":"10","key":"9","first-page":"858","volume":"91","year":"2001","journal-title":"South African Medical Journal"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-103"},{"issue":"2","key":"11","first-page":"F89","volume":"88","year":"2003","journal-title":"Archives of Disease in Childhood"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2008.01.016"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.05.009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02767.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1834"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-011-0584-9"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1086\/591323"}],"container-title":["ISRN Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/508512.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/508512.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/508512.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T05:52:59Z","timestamp":1714283579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2012\/508512\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,5]]},"references-count":17,"alternative-id":["508512","508512"],"URL":"https:\/\/doi.org\/10.5402\/2012\/508512","relation":{},"ISSN":["2090-4703"],"issn-type":[{"value":"2090-4703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,5]]}}}