{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:10:09Z","timestamp":1707509409129},"reference-count":17,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T00:00:00Z","timestamp":1348704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Oncology"],"published-print":{"date-parts":[[2012,9,27]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To determine the diagnostic accuracy of DOBIComfortScan in patients with Breast Imaging Reporting suspect breast lesions (BI-RADS) 4-5 breast lesions. <jats:italic>Materials and Methods<\/jats:italic>. One-hundred and thirteen patients underwent DOBIComfortScan examination before surgery. Twelve parameters were taken into consideration to define DOBI findings. <jats:italic>Results<\/jats:italic>. Twenty-seven radical mastectomies, 47 quadrantectomies and 39 wide excisions, were performed. Overall, 65 invasive cancer, 9 in situ carcinoma and 39 nonmalignant lesions, were observed. Ten out of 12 considered parameters resulted significantly in association with histology at discriminant analysis. A summation score of 30.5 resulted to be the best cut off at ROC analysis, giving a sensitivity and specificity of 80% and 87%, respectively, and a positive predictive value of 92.2%. Finally the following DOBI-BI-RADS model was developed: malignant <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mtext>B<\/mml:mtext><mml:mn>5<\/mml:mn><mml:mo>\u2265<\/mml:mo><mml:mn>38<\/mml:mn><\/mml:mrow><\/mml:math>\n score); possibly malignant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mtext>B<\/mml:mtext><mml:mn>4<\/mml:mn><mml:mo>=<\/mml:mo><mml:mn>25<\/mml:mn><mml:mo>-<\/mml:mo><mml:mn>37<\/mml:mn><\/mml:mrow><\/mml:math> score); benign but the possibility of malignancy cannot be excluded (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mtext>B<\/mml:mtext><mml:mn>3<\/mml:mn><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><mml:mo>-<\/mml:mo><mml:mn>24<\/mml:mn><\/mml:mrow><\/mml:math> score); benign (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mtext>B<\/mml:mtext><mml:mn>2<\/mml:mn><mml:mo>&lt;<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:mrow><\/mml:math> score). <jats:italic>Conclusion<\/jats:italic>. definition of other parameters permits to improve the accuracy of this procedure. Further studies are warranted to define the potential role of DOBIComfortScan in breast cancer imaging.<\/jats:p>","DOI":"10.5402\/2012\/631917","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T06:32:26Z","timestamp":1348986746000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["The Dynamic Optical Breast Imaging in the Preoperative Workflow of Women with Suspicious or Malignant Breast Lesions: Development of a New Comprehensive Score"],"prefix":"10.5402","volume":"2012","author":[{"given":"Massimiliano","family":"D'Aiuto","sequence":"first","affiliation":[{"name":"Department of Breast Disease, National Cancer Institute \u201cG. Pascale\u201d Foundation, Via Mariano Semmola, 80136 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Frasci","sequence":"additional","affiliation":[{"name":"Department of Breast Disease, National Cancer Institute \u201cG. Pascale\u201d Foundation, Via Mariano Semmola, 80136 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Barretta","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Cancer Institute \u201cG. Pascale\u201d Foundation, Via Mariano Semmola, 80136 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Gallipoli","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Cancer Institute \u201cG. Pascale\u201d Foundation, Via Mariano Semmola, 80136 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Maria","family":"Ciuffo","sequence":"additional","affiliation":[{"name":"Breast Unit, Clinical Institute Zucchi, Via Zucchi 24, 20052 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Musco","sequence":"additional","affiliation":[{"name":"Breast Unit, Clinical Institute Zucchi, Via Zucchi 24, 20052 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Orefice","sequence":"additional","affiliation":[{"name":"Breast Unit, Clinical Institute Pio X, Via Francesco Nava 31, 20159 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Frattini","sequence":"additional","affiliation":[{"name":"Breast Surgery Divison, Medical Institute Monterosa, Via Monterosa 3, 20149 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilves","family":"Guidi","sequence":"additional","affiliation":[{"name":"Breast Prevention Area, Physios Clinic, Via Chiesa Nord 52, 41016 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Siani","sequence":"additional","affiliation":[{"name":"Department of Breast Disease, National Cancer Institute \u201cG. Pascale\u201d Foundation, Via Mariano Semmola, 80136 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Breast Disease, National Cancer Institute \u201cG. Pascale\u201d Foundation, Via Mariano Semmola, 80136 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Crispo","sequence":"additional","affiliation":[{"name":"Epidemiology Division, National Cancer Institute \u201cG. Pascale\u201d Foundation, Via Mariano Semmola, 80136 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Montella","sequence":"additional","affiliation":[{"name":"Epidemiology Division, National Cancer Institute \u201cG. 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