{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:59:27Z","timestamp":1789772367753,"version":"4.0.1"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,3,25]],"date-time":"2012-03-25T00:00:00Z","timestamp":1332633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Hematology"],"published-print":{"date-parts":[[2012,3,25]]},"abstract":"<jats:p>Pulmonary hypertension is an emerging complication of sickle cell anaemia with associated increased risk of mortality. In order to evaluate the clinical and electrocardiographic findings in adult sickle-cell patients with pulmonary hypertension, a cross sectional study was conducted on sixty two sickle cell anaemia patients and sixty two age and sex matched normal controls. Elevated pulmonary artery pressures  (PAP), defined by PAP \u2265 30\u2009mm\u2009Hg on echocardiography,  was demonstrated in 41.9% of  patients with sickle cell anaemia and in 3.2% of the controls; , . Right ventricular hypertrophy, increased P-wave duration, QTc interval, and QTc dispersion were significantly associated with pulmonary hypertension. Significant correlation was found between mean PAP and (1) Frequency of crisis (Spearman correlation = 0.320; ), (2) body mass index (Pearson\u2019s correlation = \u22120.297; ), and (3) QTc interval (Pearson\u2019s correlation 0.261; ). Pulmonary hypertension in adult sickle anaemia patients is associated with electrocardiographic evidence of right ventricular hypertrophy, and correlates significantly with frequency of vaso-occlusive crisis, and QTc interval. The observations by this study tend to suggest that these parameters could be useful for early detection and prevention of pulmonary hypertension in patients with sickle cell anaemia.<\/jats:p>","DOI":"10.5402\/2012\/768718","type":"journal-article","created":{"date-parts":[[2012,3,25]],"date-time":"2012-03-25T21:30:33Z","timestamp":1332711033000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Clinical and Electrocardiographic Evaluation of Sickle-Cell Anaemia Patients with Pulmonary Hypertension"],"prefix":"10.5402","volume":"2012","author":[{"given":"N. 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O.","family":"Ike","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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