{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:29:50Z","timestamp":1790602190803,"version":"4.1.0"},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pediatrics"],"published-print":{"date-parts":[[2012,6,21]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Uncertainty exists concerning the necessity of 10-day antibiotic treatment of group A beta hemolytic streptococcus (GABHS) pharyngitis. <jats:italic>Objective<\/jats:italic>. To assess the incidence of GABHS recurrence and suppurative and nonsuppurative complications in relation to compliance. <jats:italic>Methods<\/jats:italic>. (Design). Prospective cohort observational study. (Subjects). 2,000 children aged 6 months to 18 years with sore throat and positive GABHS culture. (Main Outcome Measures). Recurrence of symptomatic culture positive GABHS pharyngitis, incidence of suppurative, and long-term, regional, nonsuppurative complications of GABHS pharyngitis, over a ten year period. <jats:italic>Results<\/jats:italic>. 213 (11%) of the children received no treatment. Most children received antibiotics for only 4\u20136 days (in correlation with the duration of fever, which in most cases lasted up to 3 days). Three hundred and six (15.3%) children had clinically diagnosed recurrent tonsillopharyngitis; 236 (12.3%) had positive GABHS findings within 10 to 14 days and thirty-four (1.7%) within 21\u201330 days after the index positive GABHS culture. The remaining 1.3% had no positive culture despite the clinical findings. Almost all recurrences [236 (11.6%)] occurred within 14 days and 156 (7.6%) in the fully treated group. The presence of fever during the first 3 days of the disease was the most significant predictor for recurrence. Other predictors were the age younger than 6 years and the presence of cervical lymphadenitis. No increase in the incidence of nonsuppurative or suppurative complications was noted during the 10-year follow-up period, compared to the past incidence of those complications in Israel. <jats:italic>Conclusions<\/jats:italic>. Our data suggests that the majority of children discontinue antibiotics for GABHS tonsillopharyngitis a day or two after the fever subsides. The incidence of complications in our study was not affected by this poor compliance.<\/jats:p>","DOI":"10.5402\/2012\/796389","type":"journal-article","created":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T09:32:50Z","timestamp":1343554370000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Streptococcal Pharyngitis: A Prospective Study of  Compliance and Complications"],"prefix":"10.5402","volume":"2012","author":[{"given":"E. Michael","family":"Sarrell","sequence":"first","affiliation":[{"name":"Pediatric and Adolescent Ambulatory Community Clinics-Clalit Health Care Services, 128 Alozorov Street, Tel-Aviv, Israel"},{"name":"IPROS Network of the Israel Ambulatory Pediatrics Association, Israel Ambulatory Pediatric Association, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel M.","family":"Giveon","sequence":"additional","affiliation":[{"name":"Department of Family Practice, Clalit Health Services HMO, Sharon-Shomron District and Department of Family Practice, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"6960","key":"1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/bmj.309.6960.1010","volume":"309","year":"1994","journal-title":"British Medical Journal"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(95)70300-4"},{"issue":"1","key":"3","first-page":"21","volume":"36","year":"2003","journal-title":"Journal of Microbiology, Immunology and Infection"},{"issue":"9","key":"5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1542\/pir.19-9-291","volume":"19","year":"1998","journal-title":"American Academy of Pediatrics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-5-11"},{"issue":"4","key":"7","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"8","first-page":"433","volume":"2","year":"2000","journal-title":"Israel Medical Association Journal"},{"issue":"1","key":"10a","first-page":"13","volume":"45","year":"2000","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10b","year":"1997"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2009.10.005"},{"issue":"1","key":"12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/147323000403200101","volume":"32","year":"2004","journal-title":"Journal of International Medical Research"},{"key":"13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1086\/340949","volume":"35","year":"2002","journal-title":"Clinical Infectious Diseases"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.6.5.619"},{"issue":"1","key":"15","first-page":"20","volume":"22","year":"2009","journal-title":"Revista Espanola de Quimioterapia"},{"issue":"6","key":"16","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1001\/archpedi.155.6.687","volume":"155","year":"2001","journal-title":"Archives of Pediatrics and Adolescent Medicine"},{"issue":"5","key":"17","first-page":"514","volume":"131","year":"1977","journal-title":"American Journal of Diseases of Children"},{"issue":"6","key":"18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF02722644","volume":"69","year":"2002","journal-title":"Indian Journal of Pediatrics"},{"issue":"8","key":"19","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1001\/archpedi.1997.02170450074012","volume":"151","year":"1997","journal-title":"Archives of Pediatrics and Adolescent Medicine"},{"key":"20","first-page":"1850","volume":"44","year":"1998","journal-title":"Canadian Family Physician"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1059\/0003-4819-151-11-200912010-00011"},{"issue":"2","key":"22","first-page":"78","volume":"12","year":"2010","journal-title":"Israel Medical Association Journal"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200009000-00035"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.05.015"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199809000-00012"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.4.911"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03182.x"},{"issue":"23","key":"28","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1001\/jama.287.23.3096","volume":"287","year":"2002","journal-title":"Journal of the American Medical Association"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1086\/315709"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0207-9"}],"container-title":["ISRN Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/796389.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/796389.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/796389.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:42:46Z","timestamp":1607560966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2012\/796389\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,21]]},"references-count":29,"alternative-id":["796389","796389"],"URL":"https:\/\/doi.org\/10.5402\/2012\/796389","relation":{},"ISSN":["2090-4703"],"issn-type":[{"value":"2090-4703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,21]]}}}