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Groups 2, 3, 4, and 5 were rendered unilaterally cryptorchid and treated with vehicle (10\u2009mL\/kg), vitamin E solution (75\u2009mg\/kg), vitamin C solution (1.25\u2009g\/kg), and combination of vitamin E (75\u2009mg\/kg) and vitamin C (1.25\u2009g\/kg) solutions, respectively. Germ cell count, superoxide dismutase (SOD), total protein (TP), and testicular weight (TW) were lower, but malondialdhyde (MDA) was higher in the cryptorchid rats than the sham-operated rats. When administered separately, vitamins C and E increased germ cell count, SOD, TP, and TW but did not reduce MDA in the cryptorchid rats when compared to the vehicle-treated cryptorchid rats. However, there was no significant difference in these parameters between vehicle-treated and combined vitamins C- and E-treated rats. This suggests that vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats.<\/jats:p>","DOI":"10.5402\/2012\/843569","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T21:11:59Z","timestamp":1351631519000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats"],"prefix":"10.5402","volume":"2012","author":[{"given":"Ayobami Oladele","family":"Afolabi","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Oyo, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaolu Opeyemi","family":"Olotu","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Oyo, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-9950","authenticated-orcid":true,"given":"Isiaka Abdullateef","family":"Alagbonsi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Kogi State University, PMB 1008, Anyigba, Kogi, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"23","key":"1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1001\/jama.287.23.3116","volume":"287","year":"2002","journal-title":"Journal of the American Medical Association"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00578-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305203282003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059501"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(99)01418-8"},{"issue":"5","key":"6","first-page":"R992","volume":"264","year":"1993","journal-title":"American Journal of Physiology"},{"issue":"12","key":"7","first-page":"2410","volume":"57","year":"1997","journal-title":"Cancer Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01403-3"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(90)90508-V"},{"issue":"9","key":"10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1139\/y93-109","volume":"71","year":"1993","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"5","key":"11","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1164\/ajrccm.151.5.7735589","volume":"151","year":"1995","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"5","key":"12","first-page":"R992","volume":"264","year":"1993","journal-title":"American Journal of Physiology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00752.x"},{"issue":"2","key":"14","first-page":"129","volume":"144","year":"2001","journal-title":"European Journal of Endocrinology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod46.6.1114"},{"issue":"216","key":"16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/adc.41.216.198","volume":"41","year":"1966","journal-title":"Archives of Disease in Childhood"},{"issue":"7","key":"17","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1136\/adc.67.7.892","volume":"67","year":"1992","journal-title":"Archives of Disease in Childhood"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2006.00702.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm027"},{"issue":"1","key":"20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1542\/peds.92.1.44","volume":"92","year":"1993","journal-title":"Pediatrics"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15998-9"},{"key":"22","first-page":"289","volume":"283","year":"1961","journal-title":"Acta Chirurgica Scandinavica. 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