{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:51:53Z","timestamp":1772239913083,"version":"3.50.1"},"reference-count":61,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012,9,13]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Granulosa cell tumors (GCTs), representing ~2% of ovarian tumours, are poorly understood neoplasms with unpredictable and undetermined biological behaviour.<jats:italic>Design<\/jats:italic>. 5 unusual presentations of GCT and a retrospective 14-year (1997\u20132011) surgical pathology review based on patient sex, age, tumour type and concurrent pathology findings are presented to discuss the \u201cmyths and realities\u201d of GCTs in the context of relevant evidence-based literature.<jats:italic>Results<\/jats:italic>. The 5 index cases included (1) a 5 month-old boy with a left testicular mass, (2) a 7-day-old neonate with a large complex cystic mass in the abdomen, (3) a 76-year-old woman with an umbilical mass, (4) a 64-year-old woman with a complex solid-cystic pelvic mass, and (5) a 45 year-old woman with an acute abdomen. Pathological analysis confirmed the final diagnosis as (1) juvenile GCT, (2) macrofollicular GCT, (3) recurrent GCT 32 years later, (4) collision tumour: colonic adenocarcinoma and GCT, and (5) ruptured GCT.<jats:italic>Conclusion<\/jats:italic>. GCT is best considered as an unusual indolent neoplasm of low malignant potential with late recurrences that can arise in the ovaries and testicles in both the young and the old. Multifaceted clinical presentations coupled with the unpredictable biological behaviour with late relapses are diagnostic pitfalls necessitating a high degree of suspicion for accurate clinical and pathological diagnosis.<\/jats:p>","DOI":"10.5402\/2012\/878635","type":"journal-article","created":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T21:22:30Z","timestamp":1347657750000},"page":"1-12","source":"Crossref","is-referenced-by-count":17,"title":["The Multifaceted Granulosa Cell Tumours\u2014Myths and Realities: A Review"],"prefix":"10.5402","volume":"2012","author":[{"given":"Rani","family":"Kanthan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 0W8"},{"name":"Department of Pathology and Laboratory Medicine, Royal University Hospital, 103 Hospital Drive, Room 2868, G-Wing, Saskatoon, SK, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna-Lynn","family":"Senger","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selliah","family":"Kanthan","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20798"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.1005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.019"},{"issue":"2","key":"4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1177\/000313480306900205","volume":"69","year":"2003","journal-title":"American Surgeon"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2008.08.001"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-0014"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1053\/j.anndiagpath.2004.01.007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.06.029"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.09.015"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00355-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066878"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1177\/1066896907302423"},{"issue":"1","key":"13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S1807-59322006000100013","volume":"61","year":"2006","journal-title":"Clinics"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.10.055"},{"issue":"10","key":"15","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.5858\/2000-124-1525-GCTOTA","volume":"124","year":"2000","journal-title":"Archives of Pathology and Laboratory Medicine"},{"issue":"1","key":"16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5858\/2009-0512-RSR.1","volume":"135","year":"2011","journal-title":"Archives of Pathology and Laboratory Medicine"},{"issue":"2","key":"17","first-page":"223","volume":"93","year":"2007","journal-title":"Journal of Experimental and Clinical Medicine."},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1159\/000099352"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00000478-199403000-00013","volume":"18","year":"1994","journal-title":"American Journal of Surgical Pathology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1177\/1534735408322845"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318207cbf1"},{"issue":"8","key":"22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00000478-198408000-00002","volume":"8","year":"1984","journal-title":"American Journal of Surgical Pathology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-7071(02)00586-7"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200203000-00015"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1080\/088800102753541297"},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00004347-200007000-00011","volume":"19","year":"2000","journal-title":"International Journal of Gynecological Pathology"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.08.007"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.11.126"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-008-0805-z"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.10.061"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.09.023"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00513.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0459-5"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1025-0"},{"issue":"2","key":"35","first-page":"278","volume":"74","year":"1967","journal-title":"The Journal of Obstetrics and Gynaecology of the British Commonwealth"},{"issue":"5","key":"36","first-page":"395","volume":"45","year":"2009","journal-title":"Jornal Brasileiro de Patologia e Medicina Laboratorial"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2004.00231.x"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.12.034"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.2.540"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.09.010"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000158532.90747.e7"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31820f31f6"},{"issue":"6","key":"43","first-page":"691","volume":"32","year":"2011","journal-title":"European Journal of Gynaecological Oncology"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1080\/01443610701844002"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3182307b28"},{"issue":"4","key":"46","first-page":"799","volume":"15","year":"2010","journal-title":"Journal of BUON"},{"key":"47","first-page":"Doc26","volume":"8","year":"2010","journal-title":"German Medical Science"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-5-118"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1159\/000111140"},{"issue":"2","key":"50","first-page":"247","volume":"30","year":"2009","journal-title":"Saudi Medical Journal"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.10.042"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1159\/000274590"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5279"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318196a70e"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318224e089"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90172-4"},{"issue":"4","key":"57","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1701-2163(16)30464-9","volume":"27","year":"2005","journal-title":"Journal of Obstetrics and Gynaecology Canada"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0078"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70207-3"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7800-1-4"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00865.x"}],"container-title":["ISRN Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/878635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/878635.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/878635.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T09:35:35Z","timestamp":1714383335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2012\/878635\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,13]]},"references-count":61,"alternative-id":["878635","878635"],"URL":"https:\/\/doi.org\/10.5402\/2012\/878635","relation":{},"ISSN":["2090-4444"],"issn-type":[{"value":"2090-4444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,13]]}}}