{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:56:42Z","timestamp":1770508602559,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T00:00:00Z","timestamp":1344816000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pharmacology"],"published-print":{"date-parts":[[2012,8,13]]},"abstract":"<jats:p>A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1\u2009N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated<jats:italic>in vitro<\/jats:italic>for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of<jats:italic>Jack bean<\/jats:italic>urease. The molecular docking studies were performed by docking them into the crystal structure of<jats:italic>Jack bean<\/jats:italic>urease to observe the mode of interaction of synthesized compounds. The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results.<\/jats:p>","DOI":"10.5402\/2012\/928901","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T21:30:24Z","timestamp":1344893424000},"page":"1-9","source":"Crossref","is-referenced-by-count":50,"title":["Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives"],"prefix":"10.5402","volume":"2012","author":[{"given":"Muhammad","family":"Hanif","sequence":"first","affiliation":[{"name":"Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurram","family":"Shoaib","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, 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