{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:45:51Z","timestamp":1773661551446,"version":"3.50.1"},"reference-count":17,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Hematology"],"published-print":{"date-parts":[[2012,3,27]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. This study was aimed at comparing angiogenesis, seen as microvessel density (MVD) in subtypes of non-Hodgkin\u2019s lymphoma (NHL). <jats:italic>Methods<\/jats:italic>. In this study, 64\u2009cases of NHL diagnosed over a three-year period were included along with 15 lymph node biopsies of reactive hyperplasia. NHLs were classified using REAL classification, and immunohistochemistry was performed for CD34 in all cases. CD34-stained sections were evaluated for \u201chot spots,\u201d where MVD was assessed and expressed as per mm<jats:sup>2<\/jats:sup>. Appropriate statistical methods were applied. <jats:italic>Results<\/jats:italic>. There were 6 cases of well-differentiated lymphocytic lymphoma (SLL), 21 diffuse large B-cell lymphoma (DLBCL), 15 follicular lymphoma, 10 lymphoblastic lymphoma, 7 MALToma, and 5 peripheral T-cell lymphoma (PTCL). Mean MVD was highest in reactive hyperplasia (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>191.92<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>12.16<\/mml:mn><\/mml:mrow><\/mml:math> per mm<jats:sup>2<\/jats:sup>) compared to all NHLs. Among NHLs, PTCL demonstrated the highest MVD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>183.42<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>8.24<\/mml:mn><\/mml:mrow><\/mml:math>) followed by DLBCL (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>149<\/mml:mtext><mml:mtext>.91<\/mml:mtext><mml:mo>\u00b1<\/mml:mo><mml:mtext>13<\/mml:mtext><mml:mtext>.68<\/mml:mtext><\/mml:mrow><\/mml:math>). A significant difference was found in MVD between reactive and individual lymphoma groups. SLL had significantly lower MVD than other lymphoma subtypes. <jats:italic>Conclusion<\/jats:italic>. Angiogenesis, assessed by MVD, showed significant differences among subtypes of NHL, especially the indolent types like SLL. The higher MVD in aggressive lymphomas like PTCL and DLBCL can potentially be utilized in targeted therapy with antiangiogenic drugs.<\/jats:p>","DOI":"10.5402\/2012\/943089","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T22:12:49Z","timestamp":1332886369000},"page":"1-5","source":"Crossref","is-referenced-by-count":14,"title":["Angiogenesis in Non-Hodgkin's Lymphoma: An Intercategory Comparison of Microvessel Density"],"prefix":"10.5402","volume":"2012","author":[{"given":"Deepti","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Pathology, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunjan","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leela","family":"Pant","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopal","family":"Krishan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sompal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"6","key":"1","first-page":"469","volume":"22","year":"2000","journal-title":"Analytical and Quantitative Cytology and Histology"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00666038","volume":"36","year":"1995","journal-title":"Breast Cancer Research and Treatment"},{"issue":"8","key":"3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/jcp.38.8.849","volume":"38","year":"1985","journal-title":"Journal of Clinical Pathology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1996.tb00293.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060901"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600563821"},{"issue":"5","key":"8","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","year":"1994","journal-title":"Blood"},{"issue":"3","key":"9","first-page":"728","volume":"59","year":"1999","journal-title":"Cancer Research"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00374.x"},{"issue":"10","key":"11","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1200\/JCO.1989.7.10.1518","volume":"7","year":"1989","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2133.1975.tb03076.x","volume":"92","year":"1975","journal-title":"British Journal of Dermatology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.038661"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/10428190601083241"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn666"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700697"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000123519"}],"container-title":["ISRN Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/943089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/943089.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/943089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T03:10:37Z","timestamp":1607569837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2012\/943089\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,27]]},"references-count":17,"alternative-id":["943089","943089"],"URL":"https:\/\/doi.org\/10.5402\/2012\/943089","relation":{},"ISSN":["2090-4428"],"issn-type":[{"value":"2090-4428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,27]]}}}