{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:20:29Z","timestamp":1759616429859},"reference-count":49,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Parasitology"],"published-print":{"date-parts":[[2013,12,31]]},"abstract":"<jats:p>The study of <jats:italic>Schistosoma<\/jats:italic> species has undergone a dramatic change in recent years mainly due to transcriptome, proteome, and genome analyses. In order to better understand the biology of the parasite and to develop new and more efficient\/specific drugs, scientists have now the task to translate genetic information into functional data. The present paper aims to review the use of RNA interference (RNAi), a versatile technique used in gene silencing, for the dissection of the cellular\/molecular biology of <jats:italic>Schistosoma<\/jats:italic> spp. In addition, we will review information on the recent development of a new generation of RNA-based drugs. Examples of specific experimental approaches will be presented and discussed, such as identification of gene function, development of therapies by targeting eggs, miracidia (as a strategy for environmental use), sporocysts (for infestation control in the intermediate host), and schistosomula\/adult worms (as a treatment strategy). Furthermore, some of the main advantages, drawbacks, and future directions of these new applications and techniques will also be discussed.<\/jats:p>","DOI":"10.5402\/2013\/247036","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T21:04:18Z","timestamp":1356987858000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Applications of RNA Interference in Schistosomiasis: Gene Function Identification and Development of New Therapies"],"prefix":"10.5402","volume":"2013","author":[{"given":"Tiago Campos","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of  Biology, Faculty of Philosophy, Sciences and Languages of Ribeirao Preto, University of Sao Paulo (USP), 14040 901 Ribeirao Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Carolina Silva","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Department of  Biology, Faculty of Philosophy, 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