{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:07:32Z","timestamp":1768709252687,"version":"3.49.0"},"reference-count":20,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Rheumatology"],"published-print":{"date-parts":[[2012,3,27]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The presence of anti-Ro52 antibodies has been reported in a wide variety of autoimmune diseases, particularly in myositis, scleroderma, and autoimmune liver diseases. Clinical significance of anti-Ro52 antibodies remains controversial, and studies are lacking for clarifying the association of anti-Ro52 with interstitial lung disease (ILD) in connective tissue diseases (CTD). <jats:italic>Objectives<\/jats:italic>. To determine if anti-Ro52 antibodies are associated with ILD in CTD other than scleroderma. <jats:italic>Methods<\/jats:italic>. Single-center, retrospective study based on immunoblotting panel analysis and patients clinical records. <jats:italic>Results<\/jats:italic>. In our connective tissue disease cohort, 162 patients had immunoblotting panels with anti-Ro52 reactivity analysis, 41 (25,3%) had inclusion criteria. Among the 41 selected sera, 85.4% () had anti-Ro52 reactivity. The prevalence of ILD in the positive anti-Ro52 antibodies was 71.4% (), and 16.7% () in the negative anti-Ro52 group (). Overall sensitivity (96.2%), specificity (83.3%), positive (71.4%) and negative (83.3%) predictive values of anti-Ro52 antibodies to determine ILD in CTD is detailed in this study. <jats:italic>Conclusion<\/jats:italic>. Ro52 autoantibodies are associated with ILD in CTD excluding scleroderma. We suggest that the presence of anti-Ro52 reactivity in CTD should increase the clinician curiosity for the search of ILD.<\/jats:p>","DOI":"10.5402\/2012\/415272","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T22:12:51Z","timestamp":1332886371000},"page":"1-4","source":"Crossref","is-referenced-by-count":42,"title":["Anti-Ro52 Antibodies and Interstitial Lung Disease in Connective Tissue Diseases Excluding Scleroderma"],"prefix":"10.5402","volume":"2012","author":[{"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"first","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica, Hospital de Santo Ant\u00f3nio, Centro Hospitalar do Porto, 4099-001 Porto, Portugal"}]},{"given":"Isabel","family":"Almeida","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica, Hospital de Santo Ant\u00f3nio, Centro Hospitalar do Porto, 4099-001 Porto, Portugal"},{"name":"Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 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