{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:35:35Z","timestamp":1765805735784,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Infectious Diseases"],"published-print":{"date-parts":[[2013,7,9]]},"abstract":"<jats:p>The composition of the essential oils (EO) from leaves and rhizomes of <jats:italic>Hedychium coronarium<\/jats:italic> was analyzed both by gas chromatography and gas chromatography-mass spectroscopy. Thirty and thirty-nine compounds were identified, respectively, in the oils from leaves and rhizomes, representing 88% and 86.1% of the whole compositions. Caryophyllene oxide is the major component in rhizomes while 1,8-cineole predominates in leaves oil. Essential oils and major components were tested for trypanocidal activity using procyclic forms of <jats:italic>Trypanosoma brucei<\/jats:italic> (427 and 29-13 strains). The cytotoxicity index (CI<jats:sub>50<\/jats:sub>), using the MTT colorimetric method, showed that essential oils and 1,8-cineole were inactive (&gt;100\u2009<jats:italic>\u03bc<\/jats:italic>g\u00b7mL<jats:sup>\u22121<\/jats:sup>. Nevertheless, caryophyllene oxide revealed a remarkable activity against both <jats:italic>T. brucei<\/jats:italic> strains (CI<jats:sub>50<\/jats:sub> = 65.77\u2009<jats:italic>\u03bc<\/jats:italic>g\u00b7mL<jats:sup>\u22121<\/jats:sup> and 24.53\u2009<jats:italic>\u03bc<\/jats:italic>g\u00b7mL<jats:sup>\u22121<\/jats:sup>, resp.), and the synergism between caryophyllene oxide plus pentamidine (1\u2009:\u20091, v\/v) highly increased the trypanocidal activity (&lt;1.0\u2009<jats:italic>\u03bc<\/jats:italic>g\u00b7mL<jats:sup>\u22121<\/jats:sup>).<\/jats:p>","DOI":"10.5402\/2013\/639275","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T21:01:57Z","timestamp":1373403717000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Chemical Composition and Trypanocidal Activity of the Essential Oils from <i>Hedychium coronarium<\/i> J. Koenig (Zingiberaceae)"],"prefix":"10.5402","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0762-6199","authenticated-orcid":true,"given":"Danilo Fernando","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, School of Pharmaceutical Sciences of Araraquara, UNESP, S\u00e3o Paulo State University, 14801-902 Araraquara, SP, Brazil"},{"name":"Institute of Chemistry, UNESP, S\u00e3o Paulo State University, 14800-900 Araraquara, SP, Brazil"}]},{"given":"Angela Mar\u00eda","family":"Arenas Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Pharmaceutical Sciences of Araraquara, UNESP, S\u00e3o Paulo State University, 14801-902 Araraquara, SP, Brazil"},{"name":"Institute of Chemistry, UNESP, S\u00e3o Paulo State University, 14800-900 Araraquara, SP, Brazil"}]},{"given":"Carlos","family":"Cavaleiro","sequence":"additional","affiliation":[{"name":"Center of Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0948-821X","authenticated-orcid":true,"given":"L\u00edgia","family":"Salgueiro","sequence":"additional","affiliation":[{"name":"Center of Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Gilm\u00e1rcio Zimmermann","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences of Araraquara, UNESP, S\u00e3o Paulo State University, 14801-902 Araraquara, SP, Brazil"}]},{"given":"Nath\u00e1lia Oliveira","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences of Araraquara, UNESP, S\u00e3o Paulo State University, 14801-902 Araraquara, SP, Brazil"}]},{"given":"Maria Bernadete Gon\u00e7alves","family":"Martins","sequence":"additional","affiliation":[{"name":"UNESP, S\u00e3o Paulo State University, Coast Campus, 11330-900 S\u00e3o Vicente, SP, Brazil"}]},{"given":"Regina Maria Barretto","family":"Cicarelli","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Pharmaceutical Sciences of Araraquara, UNESP, S\u00e3o Paulo State University, 14801-902 Araraquara, SP, Brazil"},{"name":"Institute of Chemistry, UNESP, S\u00e3o Paulo State University, 14800-900 Araraquara, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-1103","authenticated-orcid":true,"given":"Raquel Regina Duarte","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences of Araraquara, UNESP, S\u00e3o Paulo State University, 14801-902 Araraquara, SP, Brazil"}]}],"member":"311","reference":[{"year":"2005","key":"1"},{"volume-title":"Estudo fitoqu\u00edmico e farmacol\u00f3gico dos constituintes fixos e vol\u00e1teis de Hedychium coronarium J. 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