{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:00:27Z","timestamp":1785222027015,"version":"3.55.0"},"reference-count":47,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Pediatr"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Increasing antibiotic resistance has reduced the effectiveness of standard Helicobacter pylori  (H . pylori ) eradication therapies in children. Probiotics, particularly Lactobacillus  species, have been proposed as adjuvants to improve treatment outcomes and reduce side effects.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate the efficacy and safety of Lactobacillus spp.  alongside standard eradication therapy in pediatric populations, emphasizing globally representative evidence through inclusion of non-English studies, especially from high-prevalence regions such as China.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) from PubMed\/MEDLINE, Cochrane CENTRAL, Scopus, and four Chinese databases. Primary outcome was eradication rate; secondary outcomes included overall and specific adverse events (AEs). Subgroup analyses evaluated probiotic dosage, supplementation duration, and eradication regimen.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Thirteen RCTs involving 1428 children were included; eight were conducted in China. Lactobacillus spp.  significantly improved eradication rates [89.7% vs  72.3%; relative risk (RR) = 1.24, 95% confidence interval (CI): 1.15-1.34, I 2 = 45%]. The effect was most pronounced in triple therapy (RR = 1.28, 95%CI: 1.17-1.40) and with higher probiotic doses (\u2265 5 \u00d7 109 colony-forming units\/day; RR = 1.36, 95%CI: 1.15-1.60). Lactobacillus spp.  also significantly reduced overall AEs (RR = 0.50, 95%CI: 0.30-0.84), particularly diarrhea (RR = 0.49, 95%CI: 0.27-0.92), nausea\/vomiting (RR = 0.66, 95%CI: 0.45-0.95), and taste disturbances (RR = 0.42, 95%CI: 0.23-0.76).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Adjunctive Lactobacillus  therapy significantly enhances H. pylori  eradication rates and reduces treatment-related adverse effects in children. Its benefits are dose-dependent and most evident in triple therapy regimens. Inclusion of Chinese and other non-English studies provides the most geographically comprehensive evidence to date, supporting the use of Lactobacillus  probiotics as a complementary strategy to optimize H. pylori  management in pediatric patients across diverse global settings.<\/jats:p>","DOI":"10.5409\/wjcp.118791","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:08:04Z","timestamp":1780416484000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Lactobacillus<\/i>\n                    supplementation for\n                    <i>Helicobacter pylori<\/i>\n                    eradication in children: A language-inclusive systematic review and meta-analysis of efficacy and safety"],"prefix":"10.5409","volume":"15","author":[{"given":"Vanessa Nadia","family":"Dargenio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Begucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"La Grasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Dargenio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania Paola","family":"Castellaneta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Cristofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggiero","family":"Francavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i36.12767"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14319"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12414"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/hel.70002"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00400-4"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12314"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03816-y"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1196084"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2018.34.4.216"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2019.02.010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.26463"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-09580-3"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7742"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1120789"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3282-z"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2291-6"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/hel.70006"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1017\/rsm.2025.10047"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.7499\/j.issn.1008-8830.2017.06.012"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8464361"},{"key":"B26","unstructured":"Sun B. 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