{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:00:28Z","timestamp":1785222028210,"version":"3.55.0"},"reference-count":27,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Pediatr"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Intercellular adhesion molecule-1 (ICAM-1) plays a key role in mediating leukocyte adhesion and endothelial injury. Elevated circulating levels of soluble ICAM-1 (sICAM-1) in patients undergoing hemodialysis (HD) have been linked to a higher incidence of cardiovascular complications.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate the impact of dialysis modality and membrane performance on post-dialysis sICAM-1 levels in children undergoing maintenance HD.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This study included 26 children on low-flux HD for at least 3 months and 26 sex-matched and age-matched healthy controls. Patients were shifted to high-flux HD for 3 months, then subsequently to post-dilutional online hemodiafiltration (OL-HDF) for additional 3 months. At the end of each study phase, blood samples were obtained before and after a mid-week HD session for sICAM-1 measurement. To account for hemoconcentration, post-session ICAM-1 were hematocrit-adjusted using van Beaumont\u2019s formula yielding corrected ICAM-1 (cICAM-1).<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Circulating post-dialysis cICAM-1 levels increased significantly after low-flux HD compared with the corresponding pre-dialysis levels (P  = 0.002), and were also significantly higher than those of the control group (P  &lt; 0.001). Following conversion to high-flux HD, post-dialysis cICAM-1 concentrations decreased significantly compared to pre-dialysis values (P  &lt; 0.001), although they remained elevated compared to controls (P  = 0.026). In contrast, OL-HDF was associated with a substantial decline in post-session cICAM-1 levels (P  &lt; 0.001), yielding values comparable to those observed in the control group (P  = 0.898).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Children on maintenance HD exhibit elevated sICAM-1 levels. Our findings suggest that higher-efficiency dialysis modalities, such as OL-HDF, may attenuate dialysis-related inflammation and endothelial activation in these patients.<\/jats:p>","DOI":"10.5409\/wjcp.120090","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:08:04Z","timestamp":1780416484000},"source":"Crossref","is-referenced-by-count":0,"title":["Modality matters: Effect of dialysis modality on soluble intercellular adhesion molecule-1 in children on regular hemodialysis"],"prefix":"10.5409","volume":"15","author":[{"given":"Mohammed F","family":"Kasem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragia M","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa R","family":"Dahshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar H","family":"Elhadedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha R","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha U","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103422"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000368940"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2MR0220-549R"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400135"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.435"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00256.2017"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200811010-00010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.103553"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-66861-7_20"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10020145"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh403"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp565"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.32.5.712"},{"key":"B14","unstructured":"Sawires HK, Mohamed WA, Schaalan MF. 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