{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:56:25Z","timestamp":1781211385489,"version":"3.54.1"},"reference-count":23,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Pediatr"],"abstract":"BACKGROUND<\/jats:p>\n Down syndrome (DS) is one of the most common causes of intellectual disability. Children with DS have varying intelligence quotient (IQ) that can predict their learning abilities.<\/jats:p>\n AIM<\/jats:p>\n To assess the brain metabolic profiles of children with DS and compare them to standard controls, using magnetic resonance spectroscopy (MRS) and correlating the results with IQ.<\/jats:p>\n METHODS<\/jats:p>\n This case-control study included 40 children with DS aged 6-15 years and 40 age and sex-matched healthy children as controls. MRS was used to evaluate ratios of choline\/creatine (Cho\/Cr), N-acetyl aspartic acid\/creatine (NAA\/Cr), and myoinositol\/creatine (MI\/Cr (in the frontal, temporal, and occipital lobes and basal ganglia and compared to controls and correlated with IQ.<\/jats:p>\n RESULTS<\/jats:p>\n Children with DS showed significant reductions in NAA\/Cr and MI\/Cr and a non-significant reduction in Cho\/Cr in frontal lobes compared to controls. Additionally, we observed significant decreases in NAA\/Cr, MI\/Cr, and Cho\/Cr in the temporal and occipital lobes and basal ganglia in children with DS compared to controls. Furthermore, there was a significant correlation between IQ and metabolic ratios in the brains of children with DS.<\/jats:p>\n CONCLUSION<\/jats:p>\n Brain metabolic profile could be a good predictor of IQ in children with DS.<\/jats:p>","DOI":"10.5409\/wjcp.v12.i5.310","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T16:03:26Z","timestamp":1701965006000},"page":"310-318","source":"Crossref","is-referenced-by-count":5,"title":["Brain metabolic profile assessed by magnetic resonance spectroscopy in \u200e\u200echildren with Down syndrome: Relation to intelligence quotient"],"prefix":"10.5409","volume":"12","author":[{"given":"Nesreen Safwat","family":"El Feil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba S","family":"Elmahdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Ahmed","family":"Elmahdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abd-Elbasset","family":"Aboelezz\u200e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba S","family":"Dawoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Beltagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"B1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.11.003"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2007.08.007"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-9525(00)02172-7"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-\u200e\u200e002-0337-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2012.10.002"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s1064-\u200e\u200e9689(03)00061-8"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2013.03.004"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.11.002"},{"key":"B10","unstructured":"Nelson SJ. 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