{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T04:20:11Z","timestamp":1742271611148,"version":"3.40.1"},"reference-count":12,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Pediatr"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Cow's milk allergy (CMA) is a common condition in infants, requiring alternative protein sources in their diets. Soya milk has become a popular substitute, especially in developing countries where it is a more affordable option compared to expensive hypoallergenic feeds for infants with insufficient breast milk supply. However, recent observations have shown an increase in soya cross-allergic reactions among infants with CMA.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To determine how often infants diagnosed with CMA also had soya cross-allergy and to examine the symptoms and outcomes of these infants at 2 years of age.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>Data from two pediatric centers were analyzed, looking at clinical records of children under 2 years old diagnosed with CMA from August 2015 to July 2023, divided into two four-year periods.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>The records of 432 infants with CMA were analyzed. In the first four-year period from August 2015 to July 2019, 142 infants were studied, with 27 (19%) found to have soya-protein allergy as well. In the second four-year period, a total of 290 infants were studied, and soya allergy was found in 136 babies (47%). This represents a significant increase (P  &lt; 0.0001) in cases of soya protein cross-allergy among infants with CMA. The most common symptoms observed were gastroesophageal reflux disorder (39%), followed by failure to thrive, bloody diarrhea, watery diarrhea, and constipation. At 2 years of age, these infants showed significant growth failure compared to infants with CMA only.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>In conclusion, this study emphasizes the importance of being cautious when using soy protein in infants with cow's milk protein allergy, especially in areas where cost is a major concern.<\/jats:p>","DOI":"10.5409\/wjcp.v14.i2.101663","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T01:54:36Z","timestamp":1742262876000},"source":"Crossref","is-referenced-by-count":0,"title":["Escalation of soya cross-allergy in infants with cow's milk allergy"],"prefix":"10.5409","volume":"14","author":[{"given":"Bhaswati C","family":"Acharyya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghdeep","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.110999"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000189358.38427.cd"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/nu15183921"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01145.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.121935"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.08.020"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003897"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.025"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(99)70249-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2003.18.4.473"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2019.03.001"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.19080\/argh.2017.04.555638"}],"container-title":["World Journal of Clinical Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i2\/101663.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i2\/101663.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T01:55:07Z","timestamp":1742262907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i2\/101663.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":12,"journal-issue":{"issue":"2"},"alternative-id":["101663"],"URL":"https:\/\/doi.org\/10.5409\/wjcp.v14.i2.101663","relation":{},"ISSN":["2219-2808"],"issn-type":[{"value":"2219-2808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,9]]}}}