{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T04:10:09Z","timestamp":1750047009468,"version":"3.41.0"},"reference-count":19,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Pediatr"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Eosinophilic gastrointestinal (GI) disease (EGID) beyond eosinophilic esophagitis is not commonly reported in the developing world.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To estimate the prevalence of EGID in a selected group of pediatric patients suffering from non-functional chronic abdominal pain (CAP).<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>A retrospective analysis was conducted on case records of children with CAP. Those exhibiting clinical or laboratory alarming features underwent endoscopic evaluation. Histopathology reports from upper GI endoscopy and ileo-colonoscopy determined the diagnosis of EGID. Subsequent analyses included clinical presentations, presence of atopy in the children or family, hemoglobin, albumin, serum immunoglobulin E (IgE), fecal calprotectin levels, endoscopic appearances, treatment methods, and outcomes.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>A total of 368 children with organic CAP were subjected to endoscopic evaluation. Among them, 19 (5.2%) patients with CAP were diagnosed with EGID. The median age of the children was 11.1 years (interquartile range = 8.4-14.4). The estimated prevalence of EGID in children with organic CAP was 520\/10000 children over 5 years. Periumbilical pain was the most common site (63%). Family history of atopy, peripheral blood eosinophilia, and elevated serum IgE were the three parameters significantly associated with EGID. Clinical remission was obtained in all children at 6 months. The 47% had microscopic remission and maintained remission until a 1-year follow-up. The 53% had a fluctuating clinical course after 6 months.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>EGID beyond the esophagus is not an uncommon entity among the children of India. It can contribute significantly to the etiology of pediatric CAP.<\/jats:p>","DOI":"10.5409\/wjcp.v14.i3.101468","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T03:33:36Z","timestamp":1750044816000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-esophageal eosinophilic gastrointestinal disease and chronic abdominal pain in children: A multicenter experience"],"prefix":"10.5409","volume":"14","author":[{"given":"Bhaswati C","family":"Acharyya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghdeep","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hema","family":"Chakrabarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4203-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003877"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2350\/11-05-0130.1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000865"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002040"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.1.54"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.07.017"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.11.009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197007000-00003"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.221"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.166"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1159\/000493668"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1080\/003655201317097254"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196704062761401"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i12.2813"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2011.06.006"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2008.02.003"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.04.022"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e120"}],"container-title":["World Journal of Clinical Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i3\/101468.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i3\/101468.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T03:33:38Z","timestamp":1750044818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i3\/101468.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":19,"journal-issue":{"issue":"3"},"alternative-id":["101468"],"URL":"https:\/\/doi.org\/10.5409\/wjcp.v14.i3.101468","relation":{},"ISSN":["2219-2808"],"issn-type":[{"value":"2219-2808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,9]]}}}